Time trends of lung and larynx cancers in Italy

R. Capocaccia, A. Micheli, F. Berrino, G. Gatta, M. Sant, M. R. Ruzza, F. Valente, A. Verdecchia

Research output: Contribution to journalArticle

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Abstract

During the period 1970-1989, age-adjusted mortality rates for lung cancer in Italy increased by more than 50%, while rates for larynx cancer in males decreased by approximately 13%. This study aims to interpret this difference, which seems to contradict the finding that cigarette smoking is a common major risk factor for both lung and larynx cancer. To this end, we jointly analyzed the time trends of incidence, survival and mortality. We first examined survival data taken from the population-based Lombardy Cancer Registry (northern Italy). Based on data referring to 880 incident cases of larynx cancer, diagnosed during the period 1976-1987, we estimated a 3% annual increase in relative survival. By contrast, no significant period effect was observed for survival rates of 2,259 incident cases of lung cancer. National incidence rates were estimated using official mortality data and the above-described survival data. Age-adjusted estimated incidence rates increased, from 1970 to 1989, for both cancer sites: +55% for male lung, +56% for female lung, and +22% for male larynx. Moreover, the patterns of birth-cohort effect, which are diverging for mortality, are nearly parallel with regard to incidence. This analysis suggests that a substantial improvement in survival of larynx cancer patients may largely explain the differences in mortality trends for cancer of lung and larynx.

Original languageEnglish
Pages (from-to)154-161
Number of pages8
JournalInternational Journal of Cancer
Volume57
Issue number2
Publication statusPublished - 1994

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Laryngeal Neoplasms
Italy
Lung Neoplasms
Survival
Mortality
Incidence
Cohort Effect
Lung
Larynx
Registries
Neoplasms
Survival Rate
Smoking
Parturition
Population

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Capocaccia, R., Micheli, A., Berrino, F., Gatta, G., Sant, M., Ruzza, M. R., ... Verdecchia, A. (1994). Time trends of lung and larynx cancers in Italy. International Journal of Cancer, 57(2), 154-161.

Time trends of lung and larynx cancers in Italy. / Capocaccia, R.; Micheli, A.; Berrino, F.; Gatta, G.; Sant, M.; Ruzza, M. R.; Valente, F.; Verdecchia, A.

In: International Journal of Cancer, Vol. 57, No. 2, 1994, p. 154-161.

Research output: Contribution to journalArticle

Capocaccia, R, Micheli, A, Berrino, F, Gatta, G, Sant, M, Ruzza, MR, Valente, F & Verdecchia, A 1994, 'Time trends of lung and larynx cancers in Italy', International Journal of Cancer, vol. 57, no. 2, pp. 154-161.
Capocaccia R, Micheli A, Berrino F, Gatta G, Sant M, Ruzza MR et al. Time trends of lung and larynx cancers in Italy. International Journal of Cancer. 1994;57(2):154-161.
Capocaccia, R. ; Micheli, A. ; Berrino, F. ; Gatta, G. ; Sant, M. ; Ruzza, M. R. ; Valente, F. ; Verdecchia, A. / Time trends of lung and larynx cancers in Italy. In: International Journal of Cancer. 1994 ; Vol. 57, No. 2. pp. 154-161.
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