Time up and go task performance improves after transcranial direct current stimulation in patient affected by Parkinson's disease

Rosa Manenti, Michela Brambilla, Sandra Rosini, Italo Orizio, Clarissa Ferrari, Barbara Borroni, Maria Cotelli

Research output: Contribution to journalArticle

Abstract

Locomotor disturbances represent one of the major distress in everyday life in people with Parkinson's disease (PD). Timed up and go test (TUG) has been advocated a useful and reliable tool for quantifying locomotor performance. The aim of this study was to assess the effect of anodal transcranial direct current stimulation (tDCS) applied over the dorsolateral prefrontal cortex (DLPFC) during timed up and go test (TUG) in a group of patients with PD. Ten participants underwent two sessions of anodal tDCS (left and right) and one session of placebo tDCS. TUG was performed before and after each tDCS session (anodal or placebo). A significant motor improvement after right DLPFC stimulation vs. placebo stimulation was observed. These results suggest that anodal tDCS can be a relevant tool to modulate walking abilities in PD.

Original languageEnglish
Pages (from-to)74-77
Number of pages4
JournalNeuroscience Letters
Volume580
DOIs
Publication statusPublished - Sep 19 2014

Keywords

  • Cognitive impairment
  • Executive functions
  • Movement disorders
  • Non-invasive brain stimulation
  • Rehabilitation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

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