Timed flat infusion of 5-fluorouracil increases the tolerability of 5-fluorouracil/docetaxel regimen in metastatic breast cancer: A dose-finding study

C. Ficorella, M. F. Morelli, E. Ricevuto, K. Cannita, G. Porzio, P. Lanfiuti Baldi, G. Cianci, Z. C. Di Rocco, C. Natoli, N. Tinari, F. De Galitiis, F. Calista, P. Marchetti

Research output: Contribution to journalArticlepeer-review

Abstract

A dose-finding study was undertaken to determine the maximum-tolerated dose, and the recommended dose of docetaxel in combination with 12-h timed (22:00-10:00) flat infusion of 5-fluorouracil (5-FU) in metastatic breast cancer patients. This schedule seems to reduce the occurrence of stomatitis of the docetaxel and infusional 5-FU regimen.

Original languageEnglish
Pages (from-to)618-620
Number of pages3
JournalBritish Journal of Cancer
Volume91
Issue number4
Publication statusPublished - Aug 16 2004

Keywords

  • 5-fluorouracil
  • Breast cancer
  • Docetaxel

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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