Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy: An observational study

E. S. Mazzone, Giorgia Coratti, M. P. Sormani, S. Messina, M. Pane, Adele D'Amico, Giulia Colia, Lavinia Fanelli, Angela Berardinelli, Alice Gardani, Valentina Lanzillotta, Paola D'Ambrosio, Roberta Petillo, F. Cavallaro, Silvia Frosini, L. Bello, Serena Bonfiglio, Roberto De Sanctis, Enrica Rolle, Nicola ForcinaFrancesca Magri, Gian Luca Vita, Concetta Palermo, M. Alice Donati, Elena Procopio, Maria Teresa Arnoldi, Giovanni Baranello, T. Mongini, Antonella Pini, Roberta Battini, E. Pegoraro, Yvan Torrente, Stefano Previtali, Claudio Bruno, L. Politano, Giacomo Pietro Comi, Maria Grazia D'Angelo, Enrico Silvio Bertini, E. Mercuri

Research output: Contribution to journalArticle

Abstract

Background: The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys. Subjects and methods: A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS). Results: The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p

Original languageEnglish
Article numbere0151445
JournalPLoS One
Volume11
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

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muscular dystrophy
Duchenne Muscular Dystrophy
observational studies
disease course
Observational Studies
Disease Progression
testing
Walking
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Mazzone, E. S., Coratti, G., Sormani, M. P., Messina, S., Pane, M., D'Amico, A., ... Mercuri, E. (2016). Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy: An observational study. PLoS One, 11(3), [e0151445]. https://doi.org/10.1371/journal.pone.0151445

Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy : An observational study. / Mazzone, E. S.; Coratti, Giorgia; Sormani, M. P.; Messina, S.; Pane, M.; D'Amico, Adele; Colia, Giulia; Fanelli, Lavinia; Berardinelli, Angela; Gardani, Alice; Lanzillotta, Valentina; D'Ambrosio, Paola; Petillo, Roberta; Cavallaro, F.; Frosini, Silvia; Bello, L.; Bonfiglio, Serena; De Sanctis, Roberto; Rolle, Enrica; Forcina, Nicola; Magri, Francesca; Vita, Gian Luca; Palermo, Concetta; Alice Donati, M.; Procopio, Elena; Arnoldi, Maria Teresa; Baranello, Giovanni; Mongini, T.; Pini, Antonella; Battini, Roberta; Pegoraro, E.; Torrente, Yvan; Previtali, Stefano; Bruno, Claudio; Politano, L.; Comi, Giacomo Pietro; D'Angelo, Maria Grazia; Bertini, Enrico Silvio; Mercuri, E.

In: PLoS One, Vol. 11, No. 3, e0151445, 01.03.2016.

Research output: Contribution to journalArticle

Mazzone, ES, Coratti, G, Sormani, MP, Messina, S, Pane, M, D'Amico, A, Colia, G, Fanelli, L, Berardinelli, A, Gardani, A, Lanzillotta, V, D'Ambrosio, P, Petillo, R, Cavallaro, F, Frosini, S, Bello, L, Bonfiglio, S, De Sanctis, R, Rolle, E, Forcina, N, Magri, F, Vita, GL, Palermo, C, Alice Donati, M, Procopio, E, Arnoldi, MT, Baranello, G, Mongini, T, Pini, A, Battini, R, Pegoraro, E, Torrente, Y, Previtali, S, Bruno, C, Politano, L, Comi, GP, D'Angelo, MG, Bertini, ES & Mercuri, E 2016, 'Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy: An observational study', PLoS One, vol. 11, no. 3, e0151445. https://doi.org/10.1371/journal.pone.0151445
Mazzone, E. S. ; Coratti, Giorgia ; Sormani, M. P. ; Messina, S. ; Pane, M. ; D'Amico, Adele ; Colia, Giulia ; Fanelli, Lavinia ; Berardinelli, Angela ; Gardani, Alice ; Lanzillotta, Valentina ; D'Ambrosio, Paola ; Petillo, Roberta ; Cavallaro, F. ; Frosini, Silvia ; Bello, L. ; Bonfiglio, Serena ; De Sanctis, Roberto ; Rolle, Enrica ; Forcina, Nicola ; Magri, Francesca ; Vita, Gian Luca ; Palermo, Concetta ; Alice Donati, M. ; Procopio, Elena ; Arnoldi, Maria Teresa ; Baranello, Giovanni ; Mongini, T. ; Pini, Antonella ; Battini, Roberta ; Pegoraro, E. ; Torrente, Yvan ; Previtali, Stefano ; Bruno, Claudio ; Politano, L. ; Comi, Giacomo Pietro ; D'Angelo, Maria Grazia ; Bertini, Enrico Silvio ; Mercuri, E. / Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy : An observational study. In: PLoS One. 2016 ; Vol. 11, No. 3.
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abstract = "Background: The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys. Subjects and methods: A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS). Results: The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p",
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T1 - Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy

T2 - An observational study

AU - Mazzone, E. S.

AU - Coratti, Giorgia

AU - Sormani, M. P.

AU - Messina, S.

AU - Pane, M.

AU - D'Amico, Adele

AU - Colia, Giulia

AU - Fanelli, Lavinia

AU - Berardinelli, Angela

AU - Gardani, Alice

AU - Lanzillotta, Valentina

AU - D'Ambrosio, Paola

AU - Petillo, Roberta

AU - Cavallaro, F.

AU - Frosini, Silvia

AU - Bello, L.

AU - Bonfiglio, Serena

AU - De Sanctis, Roberto

AU - Rolle, Enrica

AU - Forcina, Nicola

AU - Magri, Francesca

AU - Vita, Gian Luca

AU - Palermo, Concetta

AU - Alice Donati, M.

AU - Procopio, Elena

AU - Arnoldi, Maria Teresa

AU - Baranello, Giovanni

AU - Mongini, T.

AU - Pini, Antonella

AU - Battini, Roberta

AU - Pegoraro, E.

AU - Torrente, Yvan

AU - Previtali, Stefano

AU - Bruno, Claudio

AU - Politano, L.

AU - Comi, Giacomo Pietro

AU - D'Angelo, Maria Grazia

AU - Bertini, Enrico Silvio

AU - Mercuri, E.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background: The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys. Subjects and methods: A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS). Results: The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p

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