Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy: An observational study

E. S. Mazzone; Giorgia Coratti; M. P. Sormani; S. Messina; M. Pane; Adele D'Amico; Giulia Colia; Lavinia Fanelli; Angela Berardinelli; Alice Gardani; Valentina Lanzillotta; Paola D'Ambrosio; Roberta Petillo; F. Cavallaro; Silvia Frosini; L. Bello; Serena Bonfiglio; Roberto De Sanctis; Enrica Rolle; Nicola Forcina; Francesca Magri; Gian Luca Vita; Concetta Palermo; M. A. Donati; Elena Procopio; Maria Teresa Arnoldi; Giovanni Baranello; T. Mongini; Antonella Pini; Roberta Battini; E. Pegoraro; Yvan Torrente; Stefano Previtali; Claudio Bruno; L. Politano; Giacomo Pietro Comi; Maria Grazia D'Angelo; Enrico Silvio Bertini; E. Mercuri

doi:10.1371/journal.pone.0151445

Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy: An observational study

E. S. Mazzone, Giorgia Coratti, M. P. Sormani, S. Messina, M. Pane, Adele D'Amico, Giulia Colia, Lavinia Fanelli, Angela Berardinelli, Alice Gardani, Valentina Lanzillotta, Paola D'Ambrosio, Roberta Petillo, F. Cavallaro, Silvia Frosini, L. Bello, Serena Bonfiglio, Roberto De Sanctis, Enrica Rolle, Nicola ForcinaFrancesca Magri, Gian Luca Vita, Concetta Palermo, M. A. Donati, Elena Procopio, Maria Teresa Arnoldi, Giovanni Baranello, T. Mongini, Antonella Pini, Roberta Battini, E. Pegoraro, Yvan Torrente, Stefano Previtali, Claudio Bruno, L. Politano, Giacomo Pietro Comi, Maria Grazia D'Angelo, Enrico Silvio Bertini, E. Mercuri

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys. Subjects and methods: A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS). Results: The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p

Original language	English
Article number	e0151445
Journal	PLoS One
Volume	11
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0151445
Publication status	Published - Mar 1 2016

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Mazzone, E. S., Coratti, G., Sormani, M. P., Messina, S., Pane, M., D'Amico, A., Colia, G., Fanelli, L., Berardinelli, A., Gardani, A., Lanzillotta, V., D'Ambrosio, P., Petillo, R., Cavallaro, F., Frosini, S., Bello, L., Bonfiglio, S., De Sanctis, R., Rolle, E., ... Mercuri, E. (2016). Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy: An observational study. PLoS One, 11(3), [e0151445]. https://doi.org/10.1371/journal.pone.0151445

Mazzone, ES, Coratti, G, Sormani, MP, Messina, S, Pane, M, D'Amico, A , Colia, G, Fanelli, L, Berardinelli, A, Gardani, A, Lanzillotta, V, D'Ambrosio, P, Petillo, R, Cavallaro, F, Frosini, S, Bello, L, Bonfiglio, S, De Sanctis, R, Rolle, E, Forcina, N, Magri, F, Vita, GL, Palermo, C, Donati, MA, Procopio, E, Arnoldi, MT, Baranello, G, Mongini, T, Pini, A , Battini, R, Pegoraro, E, Torrente, Y , Previtali, S , Bruno, C, Politano, L, Comi, GP , D'Angelo, MG, Bertini, ES & Mercuri, E 2016, 'Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy: An observational study', PLoS One, vol. 11, no. 3, e0151445. https://doi.org/10.1371/journal.pone.0151445

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title = "Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy: An observational study",

abstract = "Background: The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys. Subjects and methods: A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS). Results: The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p",

author = "Mazzone, {E. S.} and Giorgia Coratti and Sormani, {M. P.} and S. Messina and M. Pane and Adele D'Amico and Giulia Colia and Lavinia Fanelli and Angela Berardinelli and Alice Gardani and Valentina Lanzillotta and Paola D'Ambrosio and Roberta Petillo and F. Cavallaro and Silvia Frosini and L. Bello and Serena Bonfiglio and {De Sanctis}, Roberto and Enrica Rolle and Nicola Forcina and Francesca Magri and Vita, {Gian Luca} and Concetta Palermo and Donati, {M. A.} and Elena Procopio and Arnoldi, {Maria Teresa} and Giovanni Baranello and T. Mongini and Antonella Pini and Roberta Battini and E. Pegoraro and Yvan Torrente and Stefano Previtali and Claudio Bruno and L. Politano and Comi, {Giacomo Pietro} and D'Angelo, {Maria Grazia} and Bertini, {Enrico Silvio} and E. Mercuri",

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T1 - Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy

T2 - An observational study

AU - Mazzone, E. S.

AU - Coratti, Giorgia

AU - Sormani, M. P.

AU - Messina, S.

AU - Pane, M.

AU - D'Amico, Adele

AU - Colia, Giulia

AU - Fanelli, Lavinia

AU - Berardinelli, Angela

AU - Gardani, Alice

AU - Lanzillotta, Valentina

AU - D'Ambrosio, Paola

AU - Petillo, Roberta

AU - Cavallaro, F.

AU - Frosini, Silvia

AU - Bello, L.

AU - Bonfiglio, Serena

AU - De Sanctis, Roberto

AU - Rolle, Enrica

AU - Forcina, Nicola

AU - Magri, Francesca

AU - Vita, Gian Luca

AU - Palermo, Concetta

AU - Donati, M. A.

AU - Procopio, Elena

AU - Arnoldi, Maria Teresa

AU - Baranello, Giovanni

AU - Mongini, T.

AU - Pini, Antonella

AU - Battini, Roberta

AU - Pegoraro, E.

AU - Torrente, Yvan

AU - Previtali, Stefano

AU - Bruno, Claudio

AU - Politano, L.

AU - Comi, Giacomo Pietro

AU - D'Angelo, Maria Grazia

AU - Bertini, Enrico Silvio

AU - Mercuri, E.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background: The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys. Subjects and methods: A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS). Results: The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p

AB - Background: The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys. Subjects and methods: A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS). Results: The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p

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U2 - 10.1371/journal.pone.0151445

DO - 10.1371/journal.pone.0151445

M3 - Article

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 3

M1 - e0151445

ER -

Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy: An observational study

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