TY - JOUR
T1 - Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy
T2 - An observational study
AU - Mazzone, E. S.
AU - Coratti, Giorgia
AU - Sormani, M. P.
AU - Messina, S.
AU - Pane, M.
AU - D'Amico, Adele
AU - Colia, Giulia
AU - Fanelli, Lavinia
AU - Berardinelli, Angela
AU - Gardani, Alice
AU - Lanzillotta, Valentina
AU - D'Ambrosio, Paola
AU - Petillo, Roberta
AU - Cavallaro, F.
AU - Frosini, Silvia
AU - Bello, L.
AU - Bonfiglio, Serena
AU - De Sanctis, Roberto
AU - Rolle, Enrica
AU - Forcina, Nicola
AU - Magri, Francesca
AU - Vita, Gian Luca
AU - Palermo, Concetta
AU - Donati, M. A.
AU - Procopio, Elena
AU - Arnoldi, Maria Teresa
AU - Baranello, Giovanni
AU - Mongini, T.
AU - Pini, Antonella
AU - Battini, Roberta
AU - Pegoraro, E.
AU - Torrente, Yvan
AU - Previtali, Stefano
AU - Bruno, Claudio
AU - Politano, L.
AU - Comi, Giacomo Pietro
AU - D'Angelo, Maria Grazia
AU - Bertini, Enrico Silvio
AU - Mercuri, E.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background: The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys. Subjects and methods: A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS). Results: The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p
AB - Background: The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys. Subjects and methods: A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS). Results: The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p
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U2 - 10.1371/journal.pone.0151445
DO - 10.1371/journal.pone.0151445
M3 - Article
VL - 11
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 3
M1 - e0151445
ER -