Abstract

Background: The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys. Subjects and methods: A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS). Results: The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p
Original languageEnglish
JournalPLoS One
Volume11
Issue number3
DOIs
Publication statusPublished - 2016

Keywords

  • adolescent
  • adult
  • Article
  • building
  • child
  • cohort analysis
  • disease course
  • Duchenne muscular dystrophy
  • exercise test
  • human
  • Italy
  • major clinical study
  • male
  • observational study
  • prediction
  • prospective study
  • six minute walk test
  • time
  • walking difficulty

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    Mazzone, E. S., Coratti, G., Sormani, M. P., Messina, S., Pane, M., D'Amico, A., Colia, G., Fanelli, L., Berardinelli, A. L., Gardani, A., Lanzillotta, V., D'Ambrosio, P., Petillo, R., Cavallaro, F., Frosini, S., Bello, L., Bonfiglio, S., De Sanctis, R., Rolle, E., ... Mercuri, E. (2016). Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy: An observational study. PLoS One, 11(3). https://doi.org/10.1371/journal.pone.0151445