Timing of onset affects arthritis presentation pattern in antisyntethase syndrome

Miguel A González-Gay, Carlomaurizio Montecucco, Albert Selva-O'Callaghan, Ernesto Trallero-Araguas, Ovynd Molberg, Helena Andersson, Jorge Rojas-Serrano, Diana Isabel Perez-Roman, Jutta Bauhammer, Christoph Fiehn, Rossella Neri, Simone Barsotti, Hannes M Lorenz, Andrea Doria, Anna Ghirardello, Florenzo Iannone, Margherita Giannini, Franco Franceschini, Ilaria Cavazzana, Konstantinos Triantafyllias & 31 others Maurizio Benucci, Maria Infantino, Mariangela Manfredi, Fabrizio Conti, Andreas Schwarting, Giandomenico Sebastiani, Annamaria Iuliano, Giacomo Emmi, Elena Silvestri, Marcello Govoni, Carlo Alberto Scirè, Federica Furini, Francisco Javier Lopez-Longo, Julia Martínez-Barrio, Marco Sebastiani, Andreina Manfredi, Javier Bachiller-Corral, Walter Alberto Sifuentes Giraldo, Marco A Cimmino, Claudio Cosso, Alessandro Belotti Masserini, Giovanni Cagnotto, Veronica Codullo, Mariaeva Romano, Carlo Selmi, Federica Meloni, Enrico Marchioni, Nicolò Pipitone, Claudia Alpini, Lorenzo Cavagna, AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group.

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD).

METHODS: The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2).

RESULTS: 445 (70%; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83%) from disease onset (Group 1). Patients belonging to Group 1 with respect to Group 2 had an arthritis more commonly polyarticular and symmetrical (p=0.015), IgM-Rheumatoid factor positive (p=0.035), erosions at hands and feet plain x-rays (p=0.036) and more commonly satisfying the 1987 revised classification criteria for rheumatoid arthritis (RA) (p=0.004). Features such as Raynaud's phenomenon, mechanic's hands and fever (e.g. accompanying findings) were more frequently reported in Group 2 (p=0.005).

CONCLUSIONS: In ASSD, the timing of appearance with respect to disease onset influences arthritis characteristics. In particular, RA features are more common when arthritis occurs from ASSD onset, suggesting an overlap between RA and ASSD in these patients. When arthritis appears during the follow-up, it is very close to a connective tissue disease-related arthritis. Also, the different prevalence of accompanying features between these two groups is in line with this possibility.

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalClinical and Experimental Rheumatology
Volume36
Issue number1
Publication statusPublished - Aug 5 2017

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Arthritis
Rheumatoid Arthritis
Hand
Raynaud Disease
Connective Tissue Diseases
Rheumatoid Factor
Antisynthetase syndrome
Immunoglobulin M
Foot
Fever
X-Rays
Antibodies

Keywords

  • Journal Article

Cite this

González-Gay, M. A., Montecucco, C., Selva-O'Callaghan, A., Trallero-Araguas, E., Molberg, O., Andersson, H., ... AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group. (2017). Timing of onset affects arthritis presentation pattern in antisyntethase syndrome. Clinical and Experimental Rheumatology, 36(1), 44-49.

Timing of onset affects arthritis presentation pattern in antisyntethase syndrome. / González-Gay, Miguel A; Montecucco, Carlomaurizio; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto; Molberg, Ovynd; Andersson, Helena; Rojas-Serrano, Jorge; Perez-Roman, Diana Isabel; Bauhammer, Jutta; Fiehn, Christoph; Neri, Rossella; Barsotti, Simone; Lorenz, Hannes M; Doria, Andrea; Ghirardello, Anna; Iannone, Florenzo; Giannini, Margherita; Franceschini, Franco; Cavazzana, Ilaria; Triantafyllias, Konstantinos; Benucci, Maurizio; Infantino, Maria; Manfredi, Mariangela; Conti, Fabrizio; Schwarting, Andreas; Sebastiani, Giandomenico; Iuliano, Annamaria; Emmi, Giacomo; Silvestri, Elena; Govoni, Marcello; Scirè, Carlo Alberto; Furini, Federica; Lopez-Longo, Francisco Javier; Martínez-Barrio, Julia; Sebastiani, Marco; Manfredi, Andreina; Bachiller-Corral, Javier; Sifuentes Giraldo, Walter Alberto; Cimmino, Marco A; Cosso, Claudio; Belotti Masserini, Alessandro; Cagnotto, Giovanni; Codullo, Veronica; Romano, Mariaeva; Selmi, Carlo; Meloni, Federica; Marchioni, Enrico; Pipitone, Nicolò; Alpini, Claudia; Cavagna, Lorenzo; AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group.

In: Clinical and Experimental Rheumatology, Vol. 36, No. 1, 05.08.2017, p. 44-49.

Research output: Contribution to journalArticle

González-Gay, MA, Montecucco, C, Selva-O'Callaghan, A, Trallero-Araguas, E, Molberg, O, Andersson, H, Rojas-Serrano, J, Perez-Roman, DI, Bauhammer, J, Fiehn, C, Neri, R, Barsotti, S, Lorenz, HM, Doria, A, Ghirardello, A, Iannone, F, Giannini, M, Franceschini, F, Cavazzana, I, Triantafyllias, K, Benucci, M, Infantino, M, Manfredi, M, Conti, F, Schwarting, A, Sebastiani, G, Iuliano, A, Emmi, G, Silvestri, E, Govoni, M, Scirè, CA, Furini, F, Lopez-Longo, FJ, Martínez-Barrio, J, Sebastiani, M, Manfredi, A, Bachiller-Corral, J, Sifuentes Giraldo, WA, Cimmino, MA, Cosso, C, Belotti Masserini, A, Cagnotto, G, Codullo, V, Romano, M, Selmi, C, Meloni, F, Marchioni, E, Pipitone, N, Alpini, C, Cavagna, L & AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group. 2017, 'Timing of onset affects arthritis presentation pattern in antisyntethase syndrome', Clinical and Experimental Rheumatology, vol. 36, no. 1, pp. 44-49.
González-Gay MA, Montecucco C, Selva-O'Callaghan A, Trallero-Araguas E, Molberg O, Andersson H et al. Timing of onset affects arthritis presentation pattern in antisyntethase syndrome. Clinical and Experimental Rheumatology. 2017 Aug 5;36(1):44-49.
González-Gay, Miguel A ; Montecucco, Carlomaurizio ; Selva-O'Callaghan, Albert ; Trallero-Araguas, Ernesto ; Molberg, Ovynd ; Andersson, Helena ; Rojas-Serrano, Jorge ; Perez-Roman, Diana Isabel ; Bauhammer, Jutta ; Fiehn, Christoph ; Neri, Rossella ; Barsotti, Simone ; Lorenz, Hannes M ; Doria, Andrea ; Ghirardello, Anna ; Iannone, Florenzo ; Giannini, Margherita ; Franceschini, Franco ; Cavazzana, Ilaria ; Triantafyllias, Konstantinos ; Benucci, Maurizio ; Infantino, Maria ; Manfredi, Mariangela ; Conti, Fabrizio ; Schwarting, Andreas ; Sebastiani, Giandomenico ; Iuliano, Annamaria ; Emmi, Giacomo ; Silvestri, Elena ; Govoni, Marcello ; Scirè, Carlo Alberto ; Furini, Federica ; Lopez-Longo, Francisco Javier ; Martínez-Barrio, Julia ; Sebastiani, Marco ; Manfredi, Andreina ; Bachiller-Corral, Javier ; Sifuentes Giraldo, Walter Alberto ; Cimmino, Marco A ; Cosso, Claudio ; Belotti Masserini, Alessandro ; Cagnotto, Giovanni ; Codullo, Veronica ; Romano, Mariaeva ; Selmi, Carlo ; Meloni, Federica ; Marchioni, Enrico ; Pipitone, Nicolò ; Alpini, Claudia ; Cavagna, Lorenzo ; AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group. / Timing of onset affects arthritis presentation pattern in antisyntethase syndrome. In: Clinical and Experimental Rheumatology. 2017 ; Vol. 36, No. 1. pp. 44-49.
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abstract = "OBJECTIVES: To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD).METHODS: The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2).RESULTS: 445 (70{\%}; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83{\%}) from disease onset (Group 1). Patients belonging to Group 1 with respect to Group 2 had an arthritis more commonly polyarticular and symmetrical (p=0.015), IgM-Rheumatoid factor positive (p=0.035), erosions at hands and feet plain x-rays (p=0.036) and more commonly satisfying the 1987 revised classification criteria for rheumatoid arthritis (RA) (p=0.004). Features such as Raynaud's phenomenon, mechanic's hands and fever (e.g. accompanying findings) were more frequently reported in Group 2 (p=0.005).CONCLUSIONS: In ASSD, the timing of appearance with respect to disease onset influences arthritis characteristics. In particular, RA features are more common when arthritis occurs from ASSD onset, suggesting an overlap between RA and ASSD in these patients. When arthritis appears during the follow-up, it is very close to a connective tissue disease-related arthritis. Also, the different prevalence of accompanying features between these two groups is in line with this possibility.",
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T1 - Timing of onset affects arthritis presentation pattern in antisyntethase syndrome

AU - González-Gay, Miguel A

AU - Montecucco, Carlomaurizio

AU - Selva-O'Callaghan, Albert

AU - Trallero-Araguas, Ernesto

AU - Molberg, Ovynd

AU - Andersson, Helena

AU - Rojas-Serrano, Jorge

AU - Perez-Roman, Diana Isabel

AU - Bauhammer, Jutta

AU - Fiehn, Christoph

AU - Neri, Rossella

AU - Barsotti, Simone

AU - Lorenz, Hannes M

AU - Doria, Andrea

AU - Ghirardello, Anna

AU - Iannone, Florenzo

AU - Giannini, Margherita

AU - Franceschini, Franco

AU - Cavazzana, Ilaria

AU - Triantafyllias, Konstantinos

AU - Benucci, Maurizio

AU - Infantino, Maria

AU - Manfredi, Mariangela

AU - Conti, Fabrizio

AU - Schwarting, Andreas

AU - Sebastiani, Giandomenico

AU - Iuliano, Annamaria

AU - Emmi, Giacomo

AU - Silvestri, Elena

AU - Govoni, Marcello

AU - Scirè, Carlo Alberto

AU - Furini, Federica

AU - Lopez-Longo, Francisco Javier

AU - Martínez-Barrio, Julia

AU - Sebastiani, Marco

AU - Manfredi, Andreina

AU - Bachiller-Corral, Javier

AU - Sifuentes Giraldo, Walter Alberto

AU - Cimmino, Marco A

AU - Cosso, Claudio

AU - Belotti Masserini, Alessandro

AU - Cagnotto, Giovanni

AU - Codullo, Veronica

AU - Romano, Mariaeva

AU - Selmi, Carlo

AU - Meloni, Federica

AU - Marchioni, Enrico

AU - Pipitone, Nicolò

AU - Alpini, Claudia

AU - Cavagna, Lorenzo

AU - AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group.

PY - 2017/8/5

Y1 - 2017/8/5

N2 - OBJECTIVES: To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD).METHODS: The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2).RESULTS: 445 (70%; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83%) from disease onset (Group 1). Patients belonging to Group 1 with respect to Group 2 had an arthritis more commonly polyarticular and symmetrical (p=0.015), IgM-Rheumatoid factor positive (p=0.035), erosions at hands and feet plain x-rays (p=0.036) and more commonly satisfying the 1987 revised classification criteria for rheumatoid arthritis (RA) (p=0.004). Features such as Raynaud's phenomenon, mechanic's hands and fever (e.g. accompanying findings) were more frequently reported in Group 2 (p=0.005).CONCLUSIONS: In ASSD, the timing of appearance with respect to disease onset influences arthritis characteristics. In particular, RA features are more common when arthritis occurs from ASSD onset, suggesting an overlap between RA and ASSD in these patients. When arthritis appears during the follow-up, it is very close to a connective tissue disease-related arthritis. Also, the different prevalence of accompanying features between these two groups is in line with this possibility.

AB - OBJECTIVES: To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD).METHODS: The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2).RESULTS: 445 (70%; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83%) from disease onset (Group 1). Patients belonging to Group 1 with respect to Group 2 had an arthritis more commonly polyarticular and symmetrical (p=0.015), IgM-Rheumatoid factor positive (p=0.035), erosions at hands and feet plain x-rays (p=0.036) and more commonly satisfying the 1987 revised classification criteria for rheumatoid arthritis (RA) (p=0.004). Features such as Raynaud's phenomenon, mechanic's hands and fever (e.g. accompanying findings) were more frequently reported in Group 2 (p=0.005).CONCLUSIONS: In ASSD, the timing of appearance with respect to disease onset influences arthritis characteristics. In particular, RA features are more common when arthritis occurs from ASSD onset, suggesting an overlap between RA and ASSD in these patients. When arthritis appears during the follow-up, it is very close to a connective tissue disease-related arthritis. Also, the different prevalence of accompanying features between these two groups is in line with this possibility.

KW - Journal Article

M3 - Article

VL - 36

SP - 44

EP - 49

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

IS - 1

ER -