Timing della radioterapia nel trattamento del carcinoma mammario. Revisione della letteratura

Translated title of the contribution: Timing of radiotherapy in the treatment of breast cancer. A review of the literature

M. G. Trovò, M. Gigante, M. Roncadin, M. Arcicasa, R. Bortolus

Research output: Contribution to journalArticle

Abstract

Combined modality treatments are indicatedfor most patients with breast cancer. The definition of a proper treatment schedule and of the timing of each modality is a relevant issue that affects the feasibility and the clinical outcome of the treatment. A review of the literature was done on the timing of radiation therapy (RT) in the post-operative treatment ofbreast cancer. Retrospective studies and randomized clinical trials addressing the issue were considered and grouped according to the combined modality treatments performed. With regard to breast conserving surgery and adjuvant RT, it was verified that a delay up to 8 weeks between breast surgery and start of RT is not associated with an increased risk of local failure if compared with RT started within 4 weeks. Concerning breast conserving surgery followed by adjuvant RT arid chemotherapy, the choice of the best schedule is still a complex unresolved issue. More results on sequential schedule of adjuvant RT and chemotherapy from recently published randomized studies are available. The reconstruction of the breast after conservative surgery is rarely necessary and is usually performed immediately afier surgical treatment. With regard to mastectomy followed by adjuvant RT and breast reconstruction, it appears from some retrospective studies that autologous tissue transfer offers better results over implants. Concerning the transverse rectus abdominis muscle (TRAM) procedure, either immediate reconstruction before RT or delayed reconstruction afier RT was feasible without significative differences in complication rates. Further randomized clinical studies are required to address the unresolved issues linked to the timing of RT. At present the treatment plan should be based on the patient's individual circumstances with regard to risk of metastasis and local failure.

Original languageItalian
Pages (from-to)371-376
Number of pages6
JournalAnnali Italiani di Chirurgia
Volume70
Issue number3
Publication statusPublished - May 1999

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Radiotherapy
Breast Neoplasms
Therapeutics
Appointments and Schedules
Segmental Mastectomy
Mammaplasty
Retrospective Studies
Drug Therapy
Rectus Abdominis
Mastectomy
Breast
Randomized Controlled Trials
Neoplasm Metastasis
Muscles
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Timing della radioterapia nel trattamento del carcinoma mammario. Revisione della letteratura. / Trovò, M. G.; Gigante, M.; Roncadin, M.; Arcicasa, M.; Bortolus, R.

In: Annali Italiani di Chirurgia, Vol. 70, No. 3, 05.1999, p. 371-376.

Research output: Contribution to journalArticle

Trovò, M. G. ; Gigante, M. ; Roncadin, M. ; Arcicasa, M. ; Bortolus, R. / Timing della radioterapia nel trattamento del carcinoma mammario. Revisione della letteratura. In: Annali Italiani di Chirurgia. 1999 ; Vol. 70, No. 3. pp. 371-376.
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