Timing of surgery related to menstrual cycle and prognosis of premenopausal women with breast cancer

Guido Mondini, Franco Decian, Guido Sorice, Daniele Friedman, Carlo Spirito, Massimo Costantini, Maria Pia Sormani, Dario Civalleri

Research output: Contribution to journalArticlepeer-review


The influence of the timing of surgery in relation to the menstrual cycle on the survival of breast cancer patients has been both advocated and disputed. The records of 165 premenopausal M- breast cancer women consecutively operated from 1977 to 1991 were reviewed. All patients underwent modified radical mastectomies or quandrantectomies plus postoperative radio-therapy. Node-positive patients received adjuvant chemotherapy. Cox regression analysis was used to estimate the relative risk (RR) of death in three models including timing of surgery, age, histology, pT and pN. In each model, patients were divided into two groups according to the criteria proposed by Badwe, Hrushesky, and Senie. Multivariate analysis showed a significant association between pT and pN and survival, whereas no association with survival was observed for the timing of surgery according to either Badwe or Hrushesky or Senie (RR = 1.26, RR = 0.91 and RR = 0.88 respectively). Consensus on the menstrual phase related to the expected best prognosis is still required.

Original languageEnglish
Pages (from-to)787-790
Number of pages4
JournalAnticancer Research
Issue number1 B
Publication statusPublished - 1997


  • Breast neoplasms
  • Chronobiology
  • Menstrual cycle

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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