Timing the initiation of multiple myeloma.: Nature Communications

Even H. Rustad; Venkata Yellapantula; Daniel Leongamornlert; Niccolò Bolli; Guy Ledergor; Ferran Nadeu; Nicos Angelopoulos; Kevin J. Dawson; Thomas J. Mitchell; Robert J. Osborne; Bachisio Ziccheddu; Cristiana Carniti; Vittorio Montefusco; Paolo Corradini; Kenneth C. Anderson; Philippe Moreau; Elli Papaemmanuil; Ludmil B. Alexandrov; Xose S. Puente; Elias Campo; Reiner Siebert; Herve Avet-Loiseau; Ola Landgren; Nikhil Munshi; Peter J. Campbell; Francesco Maura

doi:10.1038/s41467-020-15740-9

Timing the initiation of multiple myeloma. Nature Communications

Even H. Rustad, Venkata Yellapantula, Daniel Leongamornlert, Niccolò Bolli, Guy Ledergor, Ferran Nadeu, Nicos Angelopoulos, Kevin J. Dawson, Thomas J. Mitchell, Robert J. Osborne, Bachisio Ziccheddu, Cristiana Carniti, Vittorio Montefusco, Paolo Corradini, Kenneth C. Anderson, Philippe Moreau, Elli Papaemmanuil, Ludmil B. Alexandrov, Xose S. Puente, Elias CampoReiner Siebert, Herve Avet-Loiseau, Ola Landgren, Nikhil Munshi, Peter J. Campbell, Francesco Maura

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

The evolution and progression of multiple myeloma and its precursors over time is poorly understood. Here, we investigate the landscape and timing of mutational processes shaping multiple myeloma evolution in a large cohort of 89 whole genomes and 973 exomes. We identify eight processes, including a mutational signature caused by exposure to melphalan. Reconstructing the chronological activity of each mutational signature, we estimate that the initial transformation of a germinal center B-cell usually occurred during the first 2nd-3rd decades of life. We define four main patterns of activation-induced deaminase (AID) and apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) mutagenesis over time, including a subset of patients with evidence of prolonged AID activity during the pre-malignant phase, indicating antigen-responsiveness and germinal center reentry. Our findings provide a framework to study the etiology of multiple myeloma and explore strategies for prevention and early detection.

Original language	English
Journal	Nat. Commun.
Volume	11
DOIs	https://doi.org/10.1038/s41467-020-15740-9
Publication status	Published - 2020

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10.1038/s41467-020-15740-9

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Rustad, E. H., Yellapantula, V., Leongamornlert, D., Bolli, N., Ledergor, G., Nadeu, F., Angelopoulos, N., Dawson, K. J., Mitchell, T. J., Osborne, R. J., Ziccheddu, B., Carniti, C., Montefusco, V., Corradini, P., Anderson, K. C., Moreau, P., Papaemmanuil, E., Alexandrov, L. B., Puente, X. S., ... Maura, F. (2020). Timing the initiation of multiple myeloma. Nature Communications. Nat. Commun., 11. https://doi.org/10.1038/s41467-020-15740-9

Timing the initiation of multiple myeloma. Nature Communications. / Rustad, Even H.; Yellapantula, Venkata; Leongamornlert, Daniel; Bolli, Niccolò; Ledergor, Guy; Nadeu, Ferran; Angelopoulos, Nicos; Dawson, Kevin J.; Mitchell, Thomas J.; Osborne, Robert J.; Ziccheddu, Bachisio; Carniti, Cristiana; Montefusco, Vittorio; Corradini, Paolo; Anderson, Kenneth C.; Moreau, Philippe; Papaemmanuil, Elli; Alexandrov, Ludmil B.; Puente, Xose S.; Campo, Elias; Siebert, Reiner; Avet-Loiseau, Herve; Landgren, Ola; Munshi, Nikhil; Campbell, Peter J.; Maura, Francesco.

In: Nat. Commun., Vol. 11, 2020.

Research output: Contribution to journal › Article › peer-review

Rustad, EH, Yellapantula, V, Leongamornlert, D, Bolli, N, Ledergor, G, Nadeu, F, Angelopoulos, N, Dawson, KJ, Mitchell, TJ, Osborne, RJ, Ziccheddu, B, Carniti, C, Montefusco, V, Corradini, P, Anderson, KC, Moreau, P, Papaemmanuil, E, Alexandrov, LB, Puente, XS, Campo, E, Siebert, R, Avet-Loiseau, H, Landgren, O, Munshi, N, Campbell, PJ & Maura, F 2020, 'Timing the initiation of multiple myeloma. Nature Communications', Nat. Commun., vol. 11. https://doi.org/10.1038/s41467-020-15740-9

Rustad, Even H. ; Yellapantula, Venkata ; Leongamornlert, Daniel ; Bolli, Niccolò ; Ledergor, Guy ; Nadeu, Ferran ; Angelopoulos, Nicos ; Dawson, Kevin J. ; Mitchell, Thomas J. ; Osborne, Robert J. ; Ziccheddu, Bachisio ; Carniti, Cristiana ; Montefusco, Vittorio ; Corradini, Paolo ; Anderson, Kenneth C. ; Moreau, Philippe ; Papaemmanuil, Elli ; Alexandrov, Ludmil B. ; Puente, Xose S. ; Campo, Elias ; Siebert, Reiner ; Avet-Loiseau, Herve ; Landgren, Ola ; Munshi, Nikhil ; Campbell, Peter J. ; Maura, Francesco. / Timing the initiation of multiple myeloma. Nature Communications. In: Nat. Commun. 2020 ; Vol. 11.

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title = "Timing the initiation of multiple myeloma.: Nature Communications",

abstract = "The evolution and progression of multiple myeloma and its precursors over time is poorly understood. Here, we investigate the landscape and timing of mutational processes shaping multiple myeloma evolution in a large cohort of 89 whole genomes and 973 exomes. We identify eight processes, including a mutational signature caused by exposure to melphalan. Reconstructing the chronological activity of each mutational signature, we estimate that the initial transformation of a germinal center B-cell usually occurred during the first 2nd-3rd decades of life. We define four main patterns of activation-induced deaminase (AID) and apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) mutagenesis over time, including a subset of patients with evidence of prolonged AID activity during the pre-malignant phase, indicating antigen-responsiveness and germinal center reentry. Our findings provide a framework to study the etiology of multiple myeloma and explore strategies for prevention and early detection.",

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AB - The evolution and progression of multiple myeloma and its precursors over time is poorly understood. Here, we investigate the landscape and timing of mutational processes shaping multiple myeloma evolution in a large cohort of 89 whole genomes and 973 exomes. We identify eight processes, including a mutational signature caused by exposure to melphalan. Reconstructing the chronological activity of each mutational signature, we estimate that the initial transformation of a germinal center B-cell usually occurred during the first 2nd-3rd decades of life. We define four main patterns of activation-induced deaminase (AID) and apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) mutagenesis over time, including a subset of patients with evidence of prolonged AID activity during the pre-malignant phase, indicating antigen-responsiveness and germinal center reentry. Our findings provide a framework to study the etiology of multiple myeloma and explore strategies for prevention and early detection.

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JO - Nat. Commun.

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Timing the initiation of multiple myeloma. Nature Communications

Abstract

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