TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in behçet's disease patients in two ethnic cohorts

Gorkem Turunc, Doga Coskun, Fatma Alibaz-Oner, Patrick Coit, Nursen Duzgun, Erkan Alpsoy, Sibel P. Yentur, Carlo Salvarani, Bruno Casali, Ina Kötter, Tulin Ergun, Haner Direskeneli, Amr H. Sawalha, Güher Saruhan-Direskeneli

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. The single nucleotide polymorphism (SNP) of TIRAP (Serine 180 leucine, S180L) that is shown to be associated with Behçet's disease (BD) in a European-derived cohort, but not in Middle Eastern patients is investigated in two other populations. Methods. Two cohorts of BD patients and controls from Turkey (n=797) and Italy (n=633) were genotyped by sequence specific primer-polymerase chain reaction (SSP-PCR) or TaqMan q-PCR assays. Results. Genotype and allele frequencies in TIRAP S180L (rs8177374) were not different between BD patients and controls in either ethnicity. Furthermore, a meta-analysis between the Turkish and the Italian BD cohorts did not reveal an association between this non-synonymous SNP in TIRAP and BD (meta-analysis OR=0.94, meta-analysis p=0.61, Q statistic heterogeneity p=0.11). Conclusion. TIRAP S180L gene polymorphism, which was previously shown to be associated with BD in a Caucasian population, has been replicated in either Turkish or Italian population in our study.

Original languageEnglish
JournalClinical and Experimental Rheumatology
Volume31
Issue numberSUPPL.77
Publication statusPublished - 2013

Keywords

  • Behçet's disease
  • Genetic susceptibility
  • TIRAP

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in behçet's disease patients in two ethnic cohorts'. Together they form a unique fingerprint.

Cite this