Tissue distribution of monoamine neurotransmitters in normal and regenerating arms of the feather star Antedon mediterranea

M. Daniela Candia Carnevali, Francesco Bonasoro, Roberto Invernizzi, Elisa Lucca, Ulrich Welsch, Michael C. Thorndyke

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Crinoid echinoderms can completely and rapidly regenerate arms lost following self-induced or traumatic amputation. Arm regeneration in these animals therefore provides a valuable experimental model for studying all aspects of regenerative processes, particularly with respect to the nervous system and its specific contribution to regenerative phenomena. Taking into account the primary role of the nervous system in regeneration in other invertebrates, we have investigated the specific involvement of neural factors, viz. the monoamine neurotransmitters dopamine and serotonin, in arm regeneration of Antedon mediterranea. In the present work, the presence of classical monoamines has been revealed by employing specific immunocytochemical and histofluorescence tests in association with biochemical detection by means of high pressure liquid chromatography. The distribution pattern of these neurohumoral molecules at standard regenerative stages has been compared with that of normal non-regenerating arms. Results indicate that both dopamine and serotonin dramatically change in both their distribution and concentration during the repair and regenerative processes. Their remarkably enhanced pattern during regeneration and widespread presence at the level of both nervous and non-nervous tissues indicates that they are important neural growth-promoting factors in crinoid arm regeneration.

Original languageEnglish
Pages (from-to)341-352
Number of pages12
JournalCell & Tissue Research
Volume285
Issue number2
DOIs
Publication statusPublished - 1996

Fingerprint

Feathers
Neurology
Tissue Distribution
Stars
Neurotransmitter Agents
Regeneration
Dopamine
Serotonin
High pressure liquid chromatography
Tissue
Animals
Repair
Nervous System
Association reactions
Molecules
Traumatic Amputation
Invertebrates
Intercellular Signaling Peptides and Proteins
Theoretical Models
High Pressure Liquid Chromatography

Keywords

  • Antedon mediterranea (Echinodermata)
  • Arm regeneration
  • Dopamine
  • Nervous system
  • Serotonin

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Anatomy

Cite this

Tissue distribution of monoamine neurotransmitters in normal and regenerating arms of the feather star Antedon mediterranea. / Carnevali, M. Daniela Candia; Bonasoro, Francesco; Invernizzi, Roberto; Lucca, Elisa; Welsch, Ulrich; Thorndyke, Michael C.

In: Cell & Tissue Research, Vol. 285, No. 2, 1996, p. 341-352.

Research output: Contribution to journalArticle

Carnevali, M. Daniela Candia ; Bonasoro, Francesco ; Invernizzi, Roberto ; Lucca, Elisa ; Welsch, Ulrich ; Thorndyke, Michael C. / Tissue distribution of monoamine neurotransmitters in normal and regenerating arms of the feather star Antedon mediterranea. In: Cell & Tissue Research. 1996 ; Vol. 285, No. 2. pp. 341-352.
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