Tissue engineering for cartilage repair: in vitro properties of a hyaluronan-derivative.

B. Grigolo, G. Lisignoli, A. Piacentini, M. Fiorini, L. Roseti, L. De Franceschi, E. Tognana, A. Pavesio, A. Facchini

Research output: Contribution to journalArticlepeer-review


Association of biomaterials with autologous cells can provide a new generation of implantable devices for cartilage and bone repair. Such scaffolds should provide a performed three-dimensional shape, prevent cells from floating out of the defect, have sufficient mechanical strength, facilitate uniform spread of cells, and stimulate the phenotype of transplanted cells. Hyaff-11 is a recently developed hyaluronic-acid based biodegradable polymer, that has been shown to provide successful cell scaffolds for tissue-engineered repair. The aim of this study was to evaluate in vitro the potential of Hyaff-11 to support the growth of human chondrocytes and to maintain their original phenotype. Our data indicate that human chondrocytes seeded on Hyaff-11 express and produce collagen type II and aggrecan and downregulate the production of collagen type I. These results provide an in vitro demonstration of therapeutic potential of Hyaff-11 as a delivery vehicle in tissue-engineered repair of articular cartilage defects.

Original languageEnglish
Pages (from-to)351-355
Number of pages5
JournalLa Chirurgia degli organi di movimento
Issue number4
Publication statusPublished - 2003


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