Tissue engineering for skeletal muscle regeneration

Roberto Rizzi, Claudia Bearzi, Arianna Mauretti, Sergio Bernardini, Stefano Cannata, Cesare Gargioli

Research output: Contribution to journalArticlepeer-review

Abstract

Stem cells and regenerative medicine have obtained a remarkable consent from the scientific community for their promising ability to recover aged, injured and diseased tissue. However, despite the noteworthy potential, hurdles currently hinder their use and clinical application: cell survival, immune response, tissue engraftment and efficient differentiation. Hence a new interdisciplinary scientific approach, such as tissue engineering, is going deep attempts to mimic neo-tissue-genesis as well as stem cell engraftment amelioration. Skeletal muscle tissue engineering represents a great potentiality in medicine for muscle regeneration exploiting new generation injectable hydrogel as scaffold supporting progenitor/stem cells for muscle differentiation reconstructing the natural skeletal muscle tissue architecture influenced by matrix mechanical and physical property and by a dynamic environment.

Original languageEnglish
Pages (from-to)230-234
Number of pages5
JournalMuscles, Ligaments and Tendons Journal
Volume2
Issue number3
Publication statusPublished - Jul 2012

Keywords

  • Hydrogel
  • Mesoangioblast
  • Skeletal muscle
  • Stem cell
  • Tissue engineering

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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