Tissue engineering of cartilage; can cannabinoids help?

Aoife Gowran, Katey McKayed, Manoj Kanichai, Cillian White, Nissrin Hammadi, Veronica Campbell

Research output: Contribution to journalArticlepeer-review

Abstract

This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the cannabinoid system has potential in mesenchymal stem cell based tissue-engineered cartilage repair strategies. The review discusses the potential of cannabinoids to protect against the degradation of cartilage in inflamed arthritic joints and the influence of cannabinoids on the chondrocyte precursors, mesenchymal stem cells (MSCs). We provide experimental evidence to show that activation of the cannabinoid system enhances the survival, migration and chondrogenic differentiation of MSCs, which are three major tenets behind the success of a cell-based tissue-engineered cartilage repair strategy. These findings highlight the potential for cannabinoids to provide a dual function by acting as anti-inflammatory agents as well as regulators of MSC biology in order to enhance tissue engineering strategies aimed at cartilage repair.

Original languageEnglish
Pages (from-to)2970-2985
Number of pages16
JournalPharmaceuticals
Volume3
Issue number9
DOIs
Publication statusPublished - 2010

Keywords

  • Cannabinoid receptors
  • Cartilage
  • Mesenchymal stem cells
  • Osteoarthritis
  • Phytocannabinoids

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

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