Tissue factor and atherosclerosis: Not only vessel wall-derived TF, but also platelet-associated TF

Marina Camera, Marta Brambilla, Laura Facchinetti, Paola Canzano, Rita Spirito, Laura Rossetti, Claudio Saccu, Matteo Nicola Dario Di Minno, Elena Tremoli

Research output: Contribution to journalArticle

Abstract

In the last ten years the contribution of both vessel wall-derived tissue factor (TF) and platelets to atherosclerosis has been revisited. At the beginning of the 2000 a circulating blood-borne TF has been proposed to sustain coagulation activation and propagation on the edge of a growing thrombus. Concomitantly with the observation that platelets not only contribute to thrombus formation, but also take part to the onset of the atherosclerotic lesion, evidences have been provided that they express functionally active TF, making them able to trigger the coagulation cascade.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalThrombosis Research
Volume129
Issue number3
DOIs
Publication statusPublished - Mar 2012

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Keywords

  • atherosclerosis
  • platelets
  • Tissue Factor

ASJC Scopus subject areas

  • Hematology

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