Tissue factor and homocysteine levels in ischemic heart disease are associated with angiographically documented clinical recurrences after coronary angioplasty

Rossella Marcucci, Domenico Prisco, Tamara Brunelli, Guglielmina Pepe, Anna Maria Gori, Sandra Fedi, Monia Capanni, Ignazio Simonetti, Giorgio Federici, Anna Pastore, Rosanna Abbate, Gian Franco Gensini

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Abstract

Background. In ischemic heart disease (IHD) patients high plasma levels of Tissue Factor (TF), the trigger of coagulation cascade, are present. Homocysteine (Hcy) is a risk factor for coronary artery disease, and several different pathophysiological mechanisms by which Hcy may play a role in thrombus formation have been postulated in 'in vitro' studies. We investigated the 'in vivo' role of Hcy in affecting plasma levels of TF, its inhibitor Tissue Factor Pathway inhibitor (TFPI) and hypercoagulability. Methods and Results. We investigated 119 MD patients who underwent PTCA and compared them with 103 healthy subjects. TF, TFPI, Thrombin-Antithrombin complexes (TAT) and Hcy levels were significantly higher in the patients than in the controls. A positive correlation was found between Hcy and TF (r = 0.54; p <0.0001), Hcy and TFPI (r = 0.26; p <0.05) as well as Hcy and TAT (r = 0.33; p <0.0001) levels. An inverse correlation existed between folate intake and Hcy levels (r = -0.28; p = 0.001). Hcy levels within the first quartile and in the highest quartile were associated with a lower (p (0.001) and higher (p <0.0001) rate of clinical recurrences, respectively. Patients with TF values in the first quartile had a lower rate of angiographically documented clinical recurrences as compared to those in the fourth quartile (p <0.01); those in the highest quartile of TF showed a higher rate of recurrences (p = 0.001). Multivariate analysis confirmed these results (first quartile of Hcy: OR 0.02, CI 0.002-0.27; fourth quartile of Hcy: OR 36.5, C1 3.6-365/first quartile of TF: OR 0.006, CI 0.001-0.44; fourth quartile of TF: OR 16.4, CI 3.0 - 90.0), also after adjustment for risk factors and I-Icy and TF respectively. Conclusions. In this study we show that TF, TFPI and TAT levels are correlated with Hcy plasma levels in IHD patients, providing evidence of an 'in vivo' pathophysiological mechanism of hyperhomocysteinemia. The observed association between angiographically documented clinical recurrences and TF and Hcy values awaits confirmation in studies designated to evaluate this issue on a larger number of patients.

Original languageEnglish
Pages (from-to)826-832
Number of pages7
JournalThrombosis and Haemostasis
Volume83
Issue number6
Publication statusPublished - 2000

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Keywords

  • Angioplasty
  • Coagulation
  • Coronary disease
  • Risk factors

ASJC Scopus subject areas

  • Hematology

Cite this

Marcucci, R., Prisco, D., Brunelli, T., Pepe, G., Gori, A. M., Fedi, S., Capanni, M., Simonetti, I., Federici, G., Pastore, A., Abbate, R., & Gensini, G. F. (2000). Tissue factor and homocysteine levels in ischemic heart disease are associated with angiographically documented clinical recurrences after coronary angioplasty. Thrombosis and Haemostasis, 83(6), 826-832.