Tissue Factor Expressed by Neutrophils: Another Piece in the Vascular Inflammation Puzzle

Norma Maugeri, Angelo A. Manfredi

Research output: Contribution to journalArticle

Abstract

The transition from the classic role of neutrophils as the first line of defense of the immune system to that of physiological regulators of intravascular thrombosis took nearly three decades to emerge. This transition needed time to unravel the complex links between the mechanisms that regulate hemostasis and inflammation and the innate immune response, multicellular and multifactorial processes that interact with each other. The present review is focused on the expression of tissue factor by neutrophils, a critical event in their inflammatory and thrombotic function.

Original languageEnglish
Pages (from-to)728-736
Number of pages9
JournalSeminars in Thrombosis and Hemostasis
Volume41
Issue number7
DOIs
Publication statusPublished - Sep 26 2015

Keywords

  • autoimmune diseases
  • immunothrombosis
  • neutrophils
  • thromboinflammation
  • tissue factor

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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