Tissue levels of gastrin in patients with peptic ulcer

B. Germana, P. Dal Santo, F. Vianello, D. Faggian, M. Plebani, L. Gottardello, G. Leandro, F. Di Mario, R. Naccarato

Research output: Contribution to journalArticlepeer-review

Abstract

The function of G cells has been mainly evaluated by serum gastrin. A different analytical approach considers the direct determination of gastrin levels (ng/g of wet tissue) in perendoscopic biopsies, but, up to now, the results are contradictory. In the present study we evaluated, by means of a RIA method, the concentration of gastrin (ng/g of protein nitrogen) in homogenized gastroduodenal biopsies in l27 patients with peptic ulcer and in 12 dyspeptic patients. The results demonstrated: l) a significant gradient of gastrin concentrations among the different anatomical sites, according to the distribution of the G cells; 2) a correlation with serum gastrin levels; 3) a good equivalence of gastrin content in adjacent bioptical specimens. This preliminary report indicates that it is possible directly quantitate tissue levels of gastrin by means of an accurate and simple method.

Original languageEnglish
Pages (from-to)292-294
Number of pages3
JournalMedicina - Rivista della Enciclopedia Medica Italiana
Volume10
Issue number3
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Medicine(all)

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