Tissue sampling from the common bile duct through endoscopic retrograde cholangiopancreatography, endoscopic papillo(sphinctero)tomy and drainage in juxtapapillary malignancies

Vittorio Pugliese, Daniela Barone, Sebastiano Saccomanno, Massimo Conio, Hugo Aste, Leonardo Santi

Research output: Contribution to journalArticle

Abstract

In 22 patients with radiological evidence of a malignant stricture or an obstruction of the common bile duct, endobiliary tissue specimens were obtained through endoscopic retrograde cholangiopancreatography. An endoscopic papillo(sphinctero)tomy was necessary in 9 of the 22 patients. The following techniques were employed: (1) forceps biopsy of the papillary infundibulum and/or of the common bile duct; (2) brush cytology in the same sites as above; (3) biliary juice cytology obtained by a nasobiliary drainage tube. In 8 patients, two different sampling techniques were used. The final diagnosis was established by means of pathological evaluation of surgical or necroscopic material. The diagnostic adequacy was 100% for biopsy, 88% for brush cytology, and 62% for bile cytology. The sensitivity was 100%, 66%, and 25%, respectively, for the above techniques. From 6 cases without biliary cancer, the specificity was 100%. These data show that biopsy specimens alone provide a definitive preoperative diagnosis in most cases, provided adequate samples are obtained.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalSurgical Endoscopy and Other Interventional Techniques
Volume1
Issue number2
DOIs
Publication statusPublished - Jul 1987

Keywords

  • Cholangiopancreatography
  • Endoscopic cytology
  • Endoscopic histology
  • Juxtapapillary malignancies
  • Periampullary carcinoma

ASJC Scopus subject areas

  • Surgery

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