Tissue staining for Helicobacter pylori in intestinal metaplasia: Correlation with its extension and histochemical subtypes

P. Testoni, E. Colombo, R. Scelsi, L. Cattani, F. Bagnolo, F. Lella, M. Buizza, O. Luinetti

Research output: Contribution to journalArticle

Abstract

The role played by Helicobacter pylori (Hp) infection in the occurrence of non-cardial gastric adenocarcinoma is suggestive but still debated. This study aimed to evaluate: a) the prevalence of Helicobacter-like organisms in antral bioptic specimens of 291 patients with chronic gastritis with antral atrophy and different subtypes of intestinal metaplasia (IM); b) the presence of a possible different positive tissue staining for the bacteria in the complete and incomplete intestinal metaplasia. Of the 291 patients, 222 cases (76.3%) showed type I IM, 28 cases (9.6%) type II IM and 41 cases (14.1%) type III IM. Helicobacter-like organisms were found in 42.9% of cases and positive tissue staining rate appeared to be inversely related to the extension of IM (58.7% in IM extended in less than 30% of specimens, 30.2% in IM extended between 30% and 60%, 2.7% in IM exceeding 60% of the biopsed area). The inverse correlation between lower positive tissue staining for Helicobacter-like organisms and greater extension of IM was statistically significant (p <0.001). Incomplete metaplasia appeared to be unrelated to age and associated with a lower positive tissue staining for Helicobacter-like organisms; among patients with type I metaplasia, 118/222 showed Hp-positive bioptic specimens, vs 7/69 of types II and III (p <0.001). In conclusion, positive tissue staining for Helicobacter-like organisms appeared to be significantly (p <0.001) higher in type I IM, vs types II and III, and to a lesser extent to metaplastic changes; in addition, when metaplastic changes are not greatly extended (less than 30%), the presence of the bacteria is significantly reduced in specimens with incomplete form of intestinal metaplasia in comparison with the complete one.

Original languageEnglish
Pages (from-to)285-290
Number of pages6
JournalItalian Journal of Gastroenterology
Volume27
Issue number6
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Gastroenterology

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