Tissue transglutaminase antibodies for coeliac disease screening

G. Brusco, L. Izzi, G. R. Corazza

Research output: Contribution to journalArticlepeer-review

Abstract

We have prospectively searched for IgA anti-transglutaminase antibodies by an enzyme-linked immunosorbent assay test in 20 untreated coeliacs and 21 patients with small bowel disease other than coeliac disease consecutively referred to our Malabsorption Clinic. All the untreated coeliacs and one out of 21 disease controls turned out to be positive for the presence of these antibodies. The use of the enzyme-linked immunosorbent assay test for anti-transglutaminase antibodies could represent a new screening test for coeliac disease, in fact, this new enzyme-linked immunosorbent assay test has an absolute sensitivity and a satisfactory specificity and, in comparison to antiendomysial antibodies, is less expensive and avoids the ethical problems related to the use of monkey oesophagus.

Original languageEnglish
Pages (from-to)496-497
Number of pages2
JournalItalian Journal of Gastroenterology and Hepatology
Volume30
Issue number5
Publication statusPublished - 1998

Keywords

  • Coeliac disease
  • Endomysial antibodies
  • Transglutaminase antibodies

ASJC Scopus subject areas

  • Gastroenterology

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