Tissue transglutaminase: Apoptosis versus autoimmunity

Mauro Piacentini, Vittorio Colizzi

Research output: Contribution to journalArticlepeer-review

Abstract

Autoimmune diseases are characterized by multiple autoantibodies and/or autoreactive T cells that recognize a large number of antigens. Many of these antigens undergo extensive post-translational modifications during apoptosis and act as substrates for the pro-apoptotic cystein proteases. Here, Mauro Piacentini and Vittorio Colizzi discuss the effects on autoimmunity produced by post-translational modifications of proteins catalysed by the pro- apoptotic enzyme tissue transglutaminase.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalImmunology Today
Volume20
Issue number3
DOIs
Publication statusPublished - Mar 1 1999

ASJC Scopus subject areas

  • Immunology

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