Abstract
HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD (n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.
| Original language | English |
|---|---|
| Pages (from-to) | 741-745 |
| Number of pages | 5 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 38 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Alzheimer's disease
- HSV-1
- Humoral immunity
- Magnetic resonance imaging
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Clinical Psychology
Cite this
Titers of Herpes Simplex Virus Type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease. / Mancuso, Roberta; Baglio, Francesca; Cabinio, Monia; Calabrese, Elena; Hernis, Ambra; Nemni, Raffaello; Clerici, Mario.
In: Journal of Alzheimer's Disease, Vol. 38, No. 4, 2014, p. 741-745.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Titers of Herpes Simplex Virus Type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease
AU - Mancuso, Roberta
AU - Baglio, Francesca
AU - Cabinio, Monia
AU - Calabrese, Elena
AU - Hernis, Ambra
AU - Nemni, Raffaello
AU - Clerici, Mario
PY - 2014
Y1 - 2014
N2 - HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD (n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.
AB - HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD (n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.
KW - Alzheimer's disease
KW - HSV-1
KW - Humoral immunity
KW - Magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=84890539671&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890539671&partnerID=8YFLogxK
U2 - 10.3233/JAD-130977
DO - 10.3233/JAD-130977
M3 - Article
C2 - 24072067
AN - SCOPUS:84890539671
VL - 38
SP - 741
EP - 745
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 4
ER -