Titers of Herpes Simplex Virus Type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease

Research output: Contribution to journalArticle

Abstract

HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD (n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.

Original languageEnglish
Pages (from-to)741-745
Number of pages5
JournalJournal of Alzheimer's Disease
Volume38
Issue number4
DOIs
Publication statusPublished - 2014

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Human Herpesvirus 1
Alzheimer Disease
Antibodies
Central Nervous System Infections
Seroepidemiologic Studies
Gray Matter
Immunoglobulin G
Brain
Serum

Keywords

  • Alzheimer's disease
  • HSV-1
  • Humoral immunity
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

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title = "Titers of Herpes Simplex Virus Type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease",
abstract = "HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD (n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.",
keywords = "Alzheimer's disease, HSV-1, Humoral immunity, Magnetic resonance imaging",
author = "Roberta Mancuso and Francesca Baglio and Monia Cabinio and Elena Calabrese and Ambra Hernis and Raffaello Nemni and Mario Clerici",
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T1 - Titers of Herpes Simplex Virus Type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease

AU - Mancuso, Roberta

AU - Baglio, Francesca

AU - Cabinio, Monia

AU - Calabrese, Elena

AU - Hernis, Ambra

AU - Nemni, Raffaello

AU - Clerici, Mario

PY - 2014

Y1 - 2014

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AB - HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD (n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.

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KW - HSV-1

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KW - Magnetic resonance imaging

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