Abstract
HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD (n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.
Original language | English |
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Pages (from-to) | 741-745 |
Number of pages | 5 |
Journal | Journal of Alzheimer's Disease |
Volume | 38 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- Alzheimer's disease
- HSV-1
- Humoral immunity
- Magnetic resonance imaging
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Clinical Psychology