Titers of Herpes Simplex Virus Type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease

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HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD (n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.

Original languageEnglish
Pages (from-to)741-745
Number of pages5
JournalJournal of Alzheimer's Disease
Issue number4
Publication statusPublished - 2014



  • Alzheimer's disease
  • HSV-1
  • Humoral immunity
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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