Titers of Herpes Simplex Virus Type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease

Roberta Mancuso; Francesca Baglio; Monia Cabinio; Elena Calabrese; Ambra Hernis; Raffaello Nemni; Mario Clerici

doi:10.3233/JAD-130977

Titers of Herpes Simplex Virus Type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease

Roberta Mancuso, Francesca Baglio, Monia Cabinio, Elena Calabrese, Ambra Hernis, Raffaello Nemni, Mario Clerici

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD (n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.

Original language	English
Pages (from-to)	741-745
Number of pages	5
Journal	Journal of Alzheimer's Disease
Volume	38
Issue number	4
DOIs	https://doi.org/10.3233/JAD-130977
Publication status	Published - 2014

Keywords

Alzheimer's disease
HSV-1
Humoral immunity
Magnetic resonance imaging

ASJC Scopus subject areas

Psychiatry and Mental health
Geriatrics and Gerontology
Clinical Psychology

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10.3233/JAD-130977

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Titers of Herpes Simplex Virus Type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease. / Mancuso, Roberta ; Baglio, Francesca ; Cabinio, Monia; Calabrese, Elena; Hernis, Ambra; Nemni, Raffaello; Clerici, Mario.

In: Journal of Alzheimer's Disease, Vol. 38, No. 4, 2014, p. 741-745.

Research output: Contribution to journal › Article › peer-review

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abstract = "HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD (n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.",

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AU - Mancuso, Roberta

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AU - Hernis, Ambra

AU - Nemni, Raffaello

AU - Clerici, Mario

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Titers of Herpes Simplex Virus Type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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