Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: The CIBIS-ELD trial

Hans Dirk Düngen, Svetlana Apostolović, Simone Inkrot, Elvis Tahirović, Agnieszka Töpper, Felix Mehrhof, Christiane Prettin, Biljana Putniković, Aleksandar N. Neškovi, Mirjana Krotin, Dejan Sakać, Mitja Lainščak, Frank Edelmann, Rolf Wachter, Thomas Rau, Thomas Eschenhagen, Wolfram Doehner, Stefan D. Anker, Finn Waagstein, Christoph Herrmann-LingenGoetz Gelbrich, Rainer Dietz

Research output: Contribution to journalArticlepeer-review

Abstract

AimsVarious beta-blockers with distinct pharmacological profiles are approved in heart failure, yet they remain underused and underdosed. Although potentially of major public health importance, whether one agent is superior in terms of tolerability and optimal dosing has not been investigated. The aim of this study was therefore to compare the tolerability and clinical effects of two proven beta-blockers in elderly patients with heart failure.Methods and resultsWe performed a double-blind superiority trial of bisoprolol vs. carvedilol in 883 elderly heart failure patients with reduced or preserved left ventricular ejection fraction in 41 European centres. The primary endpoint was tolerability, defined as reaching and maintaining guideline-recommended target doses after 12 weeks treatment. Adverse events and clinical parameters of patient status were secondary endpoints. None of the beta-blockers was superior with regards to tolerability: 24 [95 confidence interval (CI) 2028] of patients in the bisoprolol arm and 25 (95 CI 2129) of patients in the carvedilol arm achieved the primary endpoint (P 0.64). The use of bisoprolol resulted in greater reduction of heart rate (adjusted mean difference 2.1 b.p.m., 95 CI 0.53.6, P 0.008) and more, dose-limiting, bradycardic adverse events (16 vs. 11; P 0.02). The use of carvedilol led to a reduction of forced expiratory volume (adjusted mean difference 50 mL, 95 CI 495, P 0.03) and more, non-dose-limiting, pulmonary adverse events (10 vs. 4; P <0.001).ConclusionOverall tolerability to target doses was comparable. The pattern of intolerance, however, was different: bradycardia occurred more often in the bisoprolol group, whereas pulmonary adverse events occurred more often in the carvedilol group.

Original languageEnglish
Pages (from-to)670-680
Number of pages11
JournalEuropean Journal of Heart Failure
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Beta-blocker
  • Elderly
  • Heart failure
  • Lung function
  • Target dose
  • Tolerability

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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