TLRgeting Evasion of Immune Pathways in Glioblastoma

Gaetano Finocchiaro

Research output: Contribution to journal › Short survey

4 Citations (Scopus)

Abstract

Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.

Original languageEnglish
Pages (from-to)422-424
Number of pages3
JournalCell Stem Cell
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 6 2017

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Immune Evasion
Neoplastic Stem Cells
Glioblastoma
Toll-Like Receptor 4
Toll-Like Receptors
Immunosuppressive Agents
Brain Neoplasms
Down-Regulation
Growth
Neoplasms
Cell Self Renewal

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

Cite this

TLRgeting Evasion of Immune Pathways in Glioblastoma. / Finocchiaro, Gaetano.

In: Cell Stem Cell, Vol. 20, No. 4, 06.04.2017, p. 422-424.

Research output: Contribution to journal › Short survey

Finocchiaro, G 2017, 'TLRgeting Evasion of Immune Pathways in Glioblastoma', Cell Stem Cell, vol. 20, no. 4, pp. 422-424. https://doi.org/10.1016/j.stem.2017.03.018
Finocchiaro G. TLRgeting Evasion of Immune Pathways in Glioblastoma. Cell Stem Cell. 2017 Apr 6;20(4):422-424. https://doi.org/10.1016/j.stem.2017.03.018
Finocchiaro, Gaetano. / TLRgeting Evasion of Immune Pathways in Glioblastoma. In: Cell Stem Cell. 2017 ; Vol. 20, No. 4. pp. 422-424.
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