TLRgeting Evasion of Immune Pathways in Glioblastoma

Gaetano Finocchiaro

doi:10.1016/j.stem.2017.03.018

TLRgeting Evasion of Immune Pathways in Glioblastoma

Gaetano Finocchiaro

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Short survey

Abstract

Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.

Original language	English
Pages (from-to)	422-424
Number of pages	3
Journal	Cell Stem Cell
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2017.03.018
Publication status	Published - Apr 6 2017

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ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

Cite this

Finocchiaro, G. (2017). TLRgeting Evasion of Immune Pathways in Glioblastoma. Cell Stem Cell, 20(4), 422-424. https://doi.org/10.1016/j.stem.2017.03.018

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Access to Document

10.1016/j.stem.2017.03.018