Abstract
Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.
Original language | English |
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Pages (from-to) | 422-424 |
Number of pages | 3 |
Journal | Cell Stem Cell |
Volume | 20 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 6 2017 |
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Cell Biology