TLRgeting Evasion of Immune Pathways in Glioblastoma

Gaetano Finocchiaro

Research output: Contribution to journalShort surveypeer-review


Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.

Original languageEnglish
Pages (from-to)422-424
Number of pages3
JournalCell Stem Cell
Issue number4
Publication statusPublished - Apr 6 2017

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology


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