TLRgeting Evasion of Immune Pathways in Glioblastoma

Gaetano Finocchiaro

doi:10.1016/j.stem.2017.03.018

TLRgeting Evasion of Immune Pathways in Glioblastoma

Gaetano Finocchiaro

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Short survey › peer-review

Abstract

Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.

Original language	English
Pages (from-to)	422-424
Number of pages	3
Journal	Cell Stem Cell
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2017.03.018
Publication status	Published - Apr 6 2017

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2017.03.018

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title = "TLRgeting Evasion of Immune Pathways in Glioblastoma",

abstract = "Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.",

author = "Gaetano Finocchiaro",

year = "2017",

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N2 - Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.

AB - Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.

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TLRgeting Evasion of Immune Pathways in Glioblastoma

Abstract

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