TLRgeting Evasion of Immune Pathways in Glioblastoma

Gaetano Finocchiaro

doi:10.1016/j.stem.2017.03.018

TLRgeting Evasion of Immune Pathways in Glioblastoma

Gaetano Finocchiaro

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Short survey › peer-review

Abstract

Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.

Original language	English
Pages (from-to)	422-424
Number of pages	3
Journal	Cell Stem Cell
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2017.03.018
Publication status	Published - Apr 6 2017

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

Access to Document

10.1016/j.stem.2017.03.018

Fingerprint Dive into the research topics of 'TLRgeting Evasion of Immune Pathways in Glioblastoma'. Together they form a unique fingerprint.

Cite this

@article{d40025ce14aa4552869e1511c72be386,

title = "TLRgeting Evasion of Immune Pathways in Glioblastoma",

abstract = "Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.",

author = "Gaetano Finocchiaro",

year = "2017",

month = apr,

day = "6",

doi = "10.1016/j.stem.2017.03.018",

language = "English",

volume = "20",

pages = "422--424",

journal = "Cell Stem Cell",

issn = "1934-5909",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - TLRgeting Evasion of Immune Pathways in Glioblastoma

AU - Finocchiaro, Gaetano

PY - 2017/4/6

Y1 - 2017/4/6

N2 - Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.

AB - Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.

UR - http://www.scopus.com/inward/record.url?scp=85017159566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017159566&partnerID=8YFLogxK

U2 - 10.1016/j.stem.2017.03.018

DO - 10.1016/j.stem.2017.03.018

M3 - Short survey

C2 - 28388423

AN - SCOPUS:85017159566

VL - 20

SP - 422

EP - 424

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

IS - 4

ER -