TLRgeting Evasion of Immune Pathways in Glioblastoma

Research output: Contribution to journalShort survey

4 Citations (Scopus)

Abstract

Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.

Original languageEnglish
Pages (from-to)422-424
Number of pages3
JournalCell Stem Cell
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 6 2017

Fingerprint

Immune Evasion
Neoplastic Stem Cells
Glioblastoma
Toll-Like Receptor 4
Toll-Like Receptors
Immunosuppressive Agents
Brain Neoplasms
Down-Regulation
Growth
Neoplasms
Cell Self Renewal

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

Cite this

TLRgeting Evasion of Immune Pathways in Glioblastoma. / Finocchiaro, Gaetano.

In: Cell Stem Cell, Vol. 20, No. 4, 06.04.2017, p. 422-424.

Research output: Contribution to journalShort survey

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