TMS follow-up study in patients with vascular cognitive impairment-no dementia

Rita Bella, Raffaele Ferri, Giuseppe Lanza, Mariagiovanna Cantone, Manuela Pennisi, Valentina Puglisi, Luisa Vinciguerra, Concetto Spampinato, Tommaso Mazza, Giulia Malaguarnera, Giovanni Pennisi

Research output: Contribution to journalArticle

Abstract

Vascular cognitive impairment-no dementia (VCI-ND) is a condition at risk for future dementia and should be the target of preventive strategies. Recently, an enhanced intracortical facilitation observed in VCI-ND patients was proposed as a candidate neurophysiological marker of the disease process. The aim of this study was to monitor the excitability of the motor cortex and the functioning of excitatory/inhibitory intracortical circuits in patients with VCI-ND after a follow-up period of approximately 2 years, in order to pick out early markers of disease progression into dementia. Nine patients and 9 age-matched controls were re-evaluated for single and paired pulse TMS measures of cortical excitability, as well as for neuropsycological and functional assessment. Compared to the first evaluation, patients showed a decrease of the median resting motor threshold (rMT). Patients exhibited a significant worsening at Stroop Color-Word Test Interference scores without substantial functional impairment. Our study represents the first evidence of a decrease of rMT in VCI-ND patients during the progression of cognitive impairment. This result might be considered an index of motor cortex plasticity and interpreted as a compensatory mechanism for the loss of motor cortex neurons.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalNeuroscience Letters
Volume534
Issue number1
DOIs
Publication statusPublished - Feb 8 2013

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Blood Vessels
Dementia
Motor Cortex
Motor Neurons
Disease Progression
Cognitive Dysfunction
Color

Keywords

  • Executive dysfunction
  • Motor threshold
  • Transcranial magnetic stimulation
  • Vascular cognitive impairment-no dementia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bella, R., Ferri, R., Lanza, G., Cantone, M., Pennisi, M., Puglisi, V., ... Pennisi, G. (2013). TMS follow-up study in patients with vascular cognitive impairment-no dementia. Neuroscience Letters, 534(1), 155-159. https://doi.org/10.1016/j.neulet.2012.12.017

TMS follow-up study in patients with vascular cognitive impairment-no dementia. / Bella, Rita; Ferri, Raffaele; Lanza, Giuseppe; Cantone, Mariagiovanna; Pennisi, Manuela; Puglisi, Valentina; Vinciguerra, Luisa; Spampinato, Concetto; Mazza, Tommaso; Malaguarnera, Giulia; Pennisi, Giovanni.

In: Neuroscience Letters, Vol. 534, No. 1, 08.02.2013, p. 155-159.

Research output: Contribution to journalArticle

Bella, R, Ferri, R, Lanza, G, Cantone, M, Pennisi, M, Puglisi, V, Vinciguerra, L, Spampinato, C, Mazza, T, Malaguarnera, G & Pennisi, G 2013, 'TMS follow-up study in patients with vascular cognitive impairment-no dementia', Neuroscience Letters, vol. 534, no. 1, pp. 155-159. https://doi.org/10.1016/j.neulet.2012.12.017
Bella, Rita ; Ferri, Raffaele ; Lanza, Giuseppe ; Cantone, Mariagiovanna ; Pennisi, Manuela ; Puglisi, Valentina ; Vinciguerra, Luisa ; Spampinato, Concetto ; Mazza, Tommaso ; Malaguarnera, Giulia ; Pennisi, Giovanni. / TMS follow-up study in patients with vascular cognitive impairment-no dementia. In: Neuroscience Letters. 2013 ; Vol. 534, No. 1. pp. 155-159.
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