TMS in movement disorders

Alfredo Berardelli, Mark Hallett

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transcranial magnetic stimulation (TMS) is applied to study patients with movement disorders. This article reviews the findings of such applications in patients with Parkinson's disease, dystonia, Huntington's disease, Tourette's syndrome, and essential tremor. The findings related to Parkinson's disease are characterized by a shortening of the cortical silence period (cSP), a reduction of short intracortical inhibition, an increase in the long-lasting intracortical inhibition, and a reduction of the normal motor evoked potential facilitation after single and repetitive TMS stimuli. Studies with paired-pulse TMS have provided controversial information on cortical motor excitability in Huntington's disease. The findings in dystonia include: a reduction of the short intracortical inhibition and a shortening of the cSP. In Tourette's syndrome patients, the cSP is short and intracortical inhibition is decreased. Patients with essential tremor have normal corticospinal conduction, normal duration of the cSP, and normal intracortical inhibition. Such application of TMS has produced enormous data and continues to do so.

Original languageEnglish
Title of host publicationOxford Handbook of Transcranial Stimulation
PublisherOxford University Press
ISBN (Print)9780191744013, 9780198568926
DOIs
Publication statusPublished - Nov 21 2012

Keywords

  • Dystonia
  • Essential tremor
  • Huntington's disease
  • Movement disorders
  • Parkinson's disease
  • Tourette's syndrome
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Psychology(all)

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  • Cite this

    Berardelli, A., & Hallett, M. (2012). TMS in movement disorders. In Oxford Handbook of Transcranial Stimulation Oxford University Press. https://doi.org/10.1093/oxfordhb/9780198568926.013.0021