TMS-induced cortical potentiation during wakefulness locally increases slow wave activity during sleep

Reto Huber; Steve K. Esser; Fabio Ferrarelli; Marcello Massimini; Michael J. Peterson; Giulio Tononi

doi:10.1371/journal.pone.0000276

TMS-induced cortical potentiation during wakefulness locally increases slow wave activity during sleep

Reto Huber, Steve K. Esser, Fabio Ferrarelli, Marcello Massimini, Michael J. Peterson, Giulio Tononi

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Background. Sleep slow wave activity (SWA) is thought to reflect sleep need, increasing in proportion to the length of prior wakefulness and decreasing during sleep. However, the process responsible for SWA regulation is not known. We showed recently that SWA increases locally after a learning task involving a circumscribed brain region, suggesting that SWA may reflect plastic changes triggered by learning. Methodology/Principal Findings. To test this hypothesis directly, we used transcranial magnetic stimulation (TMS) in conjunction with high-density EEG in humans. We show that 5-Hz TMS applied to motor cortex induces a localized potentiation of TMS-evoked cortical EEG responses. We then show that, in the sleep episode following 5-Hz TMS, SWA increases markedly (+39.1±17.4%, p

Original language	English
Article number	e276
Journal	PLoS One
Volume	2
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0000276
Publication status	Published - Mar 7 2007

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

Access to Document

10.1371/journal.pone.0000276

Cite this

@article{954c77bf68ec434b9723d3737d9b238d,

title = "TMS-induced cortical potentiation during wakefulness locally increases slow wave activity during sleep",

abstract = "Background. Sleep slow wave activity (SWA) is thought to reflect sleep need, increasing in proportion to the length of prior wakefulness and decreasing during sleep. However, the process responsible for SWA regulation is not known. We showed recently that SWA increases locally after a learning task involving a circumscribed brain region, suggesting that SWA may reflect plastic changes triggered by learning. Methodology/Principal Findings. To test this hypothesis directly, we used transcranial magnetic stimulation (TMS) in conjunction with high-density EEG in humans. We show that 5-Hz TMS applied to motor cortex induces a localized potentiation of TMS-evoked cortical EEG responses. We then show that, in the sleep episode following 5-Hz TMS, SWA increases markedly (+39.1±17.4%, p",

author = "Reto Huber and Esser, {Steve K.} and Fabio Ferrarelli and Marcello Massimini and Peterson, {Michael J.} and Giulio Tononi",

year = "2007",

month = mar,

day = "7",

doi = "10.1371/journal.pone.0000276",

language = "English",

volume = "2",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "3",

}

TY - JOUR

T1 - TMS-induced cortical potentiation during wakefulness locally increases slow wave activity during sleep

AU - Huber, Reto

AU - Esser, Steve K.

AU - Ferrarelli, Fabio

AU - Massimini, Marcello

AU - Peterson, Michael J.

AU - Tononi, Giulio

PY - 2007/3/7

Y1 - 2007/3/7

N2 - Background. Sleep slow wave activity (SWA) is thought to reflect sleep need, increasing in proportion to the length of prior wakefulness and decreasing during sleep. However, the process responsible for SWA regulation is not known. We showed recently that SWA increases locally after a learning task involving a circumscribed brain region, suggesting that SWA may reflect plastic changes triggered by learning. Methodology/Principal Findings. To test this hypothesis directly, we used transcranial magnetic stimulation (TMS) in conjunction with high-density EEG in humans. We show that 5-Hz TMS applied to motor cortex induces a localized potentiation of TMS-evoked cortical EEG responses. We then show that, in the sleep episode following 5-Hz TMS, SWA increases markedly (+39.1±17.4%, p

AB - Background. Sleep slow wave activity (SWA) is thought to reflect sleep need, increasing in proportion to the length of prior wakefulness and decreasing during sleep. However, the process responsible for SWA regulation is not known. We showed recently that SWA increases locally after a learning task involving a circumscribed brain region, suggesting that SWA may reflect plastic changes triggered by learning. Methodology/Principal Findings. To test this hypothesis directly, we used transcranial magnetic stimulation (TMS) in conjunction with high-density EEG in humans. We show that 5-Hz TMS applied to motor cortex induces a localized potentiation of TMS-evoked cortical EEG responses. We then show that, in the sleep episode following 5-Hz TMS, SWA increases markedly (+39.1±17.4%, p

UR - http://www.scopus.com/inward/record.url?scp=39149130092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39149130092&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0000276

DO - 10.1371/journal.pone.0000276

M3 - Article

C2 - 17342210

AN - SCOPUS:39149130092

VL - 2

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 3

M1 - e276

ER -

TMS-induced cortical potentiation during wakefulness locally increases slow wave activity during sleep

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this