Hyperthermic Limb Perfusion (HILP) with Tumor Necrosis Factor alpha (TNFα) and interferon gamma (IFNγ) was pioneered by Lienard and Lejeune in 1988. TNFα was empirically employed at a dosage of 3-4 mg that is ten times the systemic maximum tolerated dose (MTD). Sixteen years after its first clinical application more than 300 patients have been treated and some clarifications can be made regarding three major questions: the real role of IFNγ, the TNFα dose and eligibility criteria for patient selection. A randomised phase II study has demonstrated that IFNγ does not increase significantly the efficacy but does increase side-effects. Experimental and clinical results seem to indicate that patients with bulky melanoma disease can really benefit from TNFα HILP carried out with only 1 mg.
|Number of pages||4|
|Journal||Journal of Chemotherapy|
|Issue number||SUPPL. 5|
|Publication status||Published - Nov 2004|
ASJC Scopus subject areas
- Pharmacology (medical)
- Microbiology (medical)