Abstract
TNF-α-treated osteosarcoma cells have an enhanced susceptibility to NK lysis which mostly depends on the increased expression of CD54 molecules. Since IL-1 and IL-6 share overlapping biological properties with TNF-α, we investigated whether the treatment of osteosarcoma cells with these cytokines could modify their susceptibility to NK lysis and whether these modifications were related to a different distribution of CD54, CD56 and CD58 molecules. We demonstrated that the expression of CD54 and CD58 on osteosarcomas correlated positively with the susceptibility to NK lysis and that this susceptibility was enhanced by TNF-α treatment but not by IL-1 and IL-6 stimulation.
| Original language | English |
|---|---|
| Pages (from-to) | 349-353 |
| Number of pages | 5 |
| Journal | International Journal of Oncology |
| Volume | 13 |
| Issue number | 2 |
| Publication status | Published - Aug 1998 |
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Keywords
- Adhesion molecules
- Bone remodelling cytokines
- NK lysis
- Osteosarcoma cell lines
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
TNF-α but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis. / Mariani, Erminia; Tarozzi, Andrea; Meneghetti, Alessandra; Cattini, Luca; Facchini, Andrea.
In: International Journal of Oncology, Vol. 13, No. 2, 08.1998, p. 349-353.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - TNF-α but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis
AU - Mariani, Erminia
AU - Tarozzi, Andrea
AU - Meneghetti, Alessandra
AU - Cattini, Luca
AU - Facchini, Andrea
PY - 1998/8
Y1 - 1998/8
N2 - TNF-α-treated osteosarcoma cells have an enhanced susceptibility to NK lysis which mostly depends on the increased expression of CD54 molecules. Since IL-1 and IL-6 share overlapping biological properties with TNF-α, we investigated whether the treatment of osteosarcoma cells with these cytokines could modify their susceptibility to NK lysis and whether these modifications were related to a different distribution of CD54, CD56 and CD58 molecules. We demonstrated that the expression of CD54 and CD58 on osteosarcomas correlated positively with the susceptibility to NK lysis and that this susceptibility was enhanced by TNF-α treatment but not by IL-1 and IL-6 stimulation.
AB - TNF-α-treated osteosarcoma cells have an enhanced susceptibility to NK lysis which mostly depends on the increased expression of CD54 molecules. Since IL-1 and IL-6 share overlapping biological properties with TNF-α, we investigated whether the treatment of osteosarcoma cells with these cytokines could modify their susceptibility to NK lysis and whether these modifications were related to a different distribution of CD54, CD56 and CD58 molecules. We demonstrated that the expression of CD54 and CD58 on osteosarcomas correlated positively with the susceptibility to NK lysis and that this susceptibility was enhanced by TNF-α treatment but not by IL-1 and IL-6 stimulation.
KW - Adhesion molecules
KW - Bone remodelling cytokines
KW - NK lysis
KW - Osteosarcoma cell lines
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UR - http://www.scopus.com/inward/citedby.url?scp=0031849626&partnerID=8YFLogxK
M3 - Article
C2 - 9664132
AN - SCOPUS:0031849626
VL - 13
SP - 349
EP - 353
JO - International Journal of Oncology
JF - International Journal of Oncology
SN - 1019-6439
IS - 2
ER -