TNF-α but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis

Erminia Mariani, Andrea Tarozzi, Alessandra Meneghetti, Luca Cattini, Andrea Facchini

Research output: Contribution to journalArticlepeer-review

Abstract

TNF-α-treated osteosarcoma cells have an enhanced susceptibility to NK lysis which mostly depends on the increased expression of CD54 molecules. Since IL-1 and IL-6 share overlapping biological properties with TNF-α, we investigated whether the treatment of osteosarcoma cells with these cytokines could modify their susceptibility to NK lysis and whether these modifications were related to a different distribution of CD54, CD56 and CD58 molecules. We demonstrated that the expression of CD54 and CD58 on osteosarcomas correlated positively with the susceptibility to NK lysis and that this susceptibility was enhanced by TNF-α treatment but not by IL-1 and IL-6 stimulation.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalInternational Journal of Oncology
Volume13
Issue number2
Publication statusPublished - Aug 1998

Keywords

  • Adhesion molecules
  • Bone remodelling cytokines
  • NK lysis
  • Osteosarcoma cell lines

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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