TNF-α, IL-4Rα and IL-4 polymorphisms in mild to severe asthma from Italian Caucasians

Fabio L M Ricciardolo, V. Sorbello, M. Silvestri, M. Giacomelli, V. M G Debenedetti, M. Malerba, G. Ciprandi, G. A. Rossi, A. Rossi, M. Bontempelli

Research output: Contribution to journalArticlepeer-review

Abstract

Asthma is a chronic airway inflammatory disease associated with airway hyperresponsiveness which affects subjects with genetic predisposition. An association has been reported between some polymorphisms in various cytokine genes and asthma. Most of them are single nucleotide polymorphisms (SNPs). These polymorphisms are detected in the protein coding sequence or in the promoter region thus influencing cytokine production. We investigated the involvement of SNP mapping in 5 cytokine genes in mild to severe asthmatics of Italian Caucasians. The frequency of alleles and genotypes, relatively to 10 allelic specificities of the cytokine genes, was defined in 57 asthmatics and in 124 control subjects by a Polymerase Chain Reaction-Sequence Specific Primer method. TNF-α-308A and TNF-α-238A allele frequencies were higher in asthmatics than in controls (p

Original languageEnglish
Pages (from-to)75-84
Number of pages10
JournalInternational Journal of Immunopathology and Pharmacology
Volume26
Issue number1
Publication statusPublished - Jan 2013

Keywords

  • Asthma
  • Cytokines polymorphisms
  • IL-4
  • IL-4Rα
  • TNF-α

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

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