TNF-α modulates the migratory response of mesenchymal stem cells to TRAIL

Federica Corallini, Paola Secchiero, Antonio Paolo Beltrami, Daniela Cesselli, Elisa Puppato, Roberto Ferrari, Cario Alberto Beltrami, Giorgio Zauli

Research output: Contribution to journalArticlepeer-review

Abstract

The number of circulating mesenchymal stem cells (MSC), analyzed after acute myocardial infarction (AMI), was lower in AMI patients who developed heart failure (HF) in the follow-up. Conversely, the circulating levels of tumor necrosis factor (TNF)-α, and osteoprotegerin (OPG) were higher in AMI patients who developed HF with respect to the patients who did not develop HF. In vitro exposure to TNF-α enhanced the migration of MSC in response to TNF-related apoptosis-inducing ligand (TRAIL) and significantly increased the release of OPG by endothelial cells. On the contrary, OPG dose-dependently neutralized the in vitro pro-migratory activity of TRAIL. Thus, TNF-α exhibits opposite effects on MSC migration driven by TRAIL: it is capable of potentiating MSC migration as well as of inhibiting MSC migration as an indirect consequence of OPG induction, which might result in a suboptimal recruitment of circulating MSC after AMI in those patients who develop HF in the follow-up.

Original languageEnglish
Pages (from-to)1307-1314
Number of pages8
JournalCellular and Molecular Life Sciences
Volume67
Issue number8
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Heart failure
  • Inflammation
  • Mesenchymal stem cells
  • OPG
  • TNF-α
  • TRAIL

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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