TNF-α modulates the migratory response of mesenchymal stem cells to TRAIL

Federica Corallini, Paola Secchiero, Antonio Paolo Beltrami, Daniela Cesselli, Elisa Puppato, Roberto Ferrari, Cario Alberto Beltrami, Giorgio Zauli

Research output: Contribution to journalArticle

Abstract

The number of circulating mesenchymal stem cells (MSC), analyzed after acute myocardial infarction (AMI), was lower in AMI patients who developed heart failure (HF) in the follow-up. Conversely, the circulating levels of tumor necrosis factor (TNF)-α, and osteoprotegerin (OPG) were higher in AMI patients who developed HF with respect to the patients who did not develop HF. In vitro exposure to TNF-α enhanced the migration of MSC in response to TNF-related apoptosis-inducing ligand (TRAIL) and significantly increased the release of OPG by endothelial cells. On the contrary, OPG dose-dependently neutralized the in vitro pro-migratory activity of TRAIL. Thus, TNF-α exhibits opposite effects on MSC migration driven by TRAIL: it is capable of potentiating MSC migration as well as of inhibiting MSC migration as an indirect consequence of OPG induction, which might result in a suboptimal recruitment of circulating MSC after AMI in those patients who develop HF in the follow-up.

Original languageEnglish
Pages (from-to)1307-1314
Number of pages8
JournalCellular and Molecular Life Sciences
Volume67
Issue number8
DOIs
Publication statusPublished - Apr 2010

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Keywords

  • Heart failure
  • Inflammation
  • Mesenchymal stem cells
  • OPG
  • TNF-α
  • TRAIL

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Corallini, F., Secchiero, P., Beltrami, A. P., Cesselli, D., Puppato, E., Ferrari, R., Beltrami, C. A., & Zauli, G. (2010). TNF-α modulates the migratory response of mesenchymal stem cells to TRAIL. Cellular and Molecular Life Sciences, 67(8), 1307-1314. https://doi.org/10.1007/s00018-009-0246-5