The ability of Pneumocystis carinii to induce TNF-alpha release by macrophages from adult healthy humans was investigated. Monocytes and monocytes derived macrophages produced a high amount of TNF-alpha when exposed to P. carinii cysts obtained from rats with steroid induced pneumocystosis. TNF-alpha release was P. carinii specific as shown by the inhibition exerted by the anti-P. carinii hyperimmune serum and it was not mediated by putative traces of endotoxin.
|Translated title of the contribution||TNF-alpha released in vitro by human macrophages after stimulus with murine Pneumocystis carinii|
|Number of pages||2|
|Journal||Medicina - Rivista della Enciclopedia Medica Italiana|
|Publication status||Published - 1990|
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