TNF and sTNFR1/2 plasma levels in ALS patients

Cristina Cereda, Chiara Baiocchi, Paolo Bongioanni, Emanuela Cova, Stefania Guareschi, Maria Rita Metelli, Bruno Rossi, Ilaria Sbalsi, Maria Clara Cuccia, Mauro Ceroni

Research output: Contribution to journalArticle

Abstract

The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subjects. The genetic analysis of the polymorphisms of TNF-alpha, TNF-R1 and TNF-R2 showed no statistically significant differences in alleles and genotype frequencies between patients and controls. These data suggest a participation of the immune system in response to as far unknown intracellular signals.

Original languageEnglish
Pages (from-to)123-131
Number of pages9
JournalJournal of Neuroimmunology
Volume194
Issue number1-2
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Receptors, Tumor Necrosis Factor, Type II
Amyotrophic Lateral Sclerosis
Immune System
Tumor Necrosis Factor-alpha
Tumor Necrosis Factor Receptors
Gene Frequency
Genotype
Amyotrophic lateral sclerosis 1

Keywords

  • Amyotrophic lateral sclerosis
  • Plasma
  • TNF-alpha
  • TNF-R1
  • TNF-R2

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Cereda, C., Baiocchi, C., Bongioanni, P., Cova, E., Guareschi, S., Metelli, M. R., ... Ceroni, M. (2008). TNF and sTNFR1/2 plasma levels in ALS patients. Journal of Neuroimmunology, 194(1-2), 123-131. https://doi.org/10.1016/j.jneuroim.2007.10.028

TNF and sTNFR1/2 plasma levels in ALS patients. / Cereda, Cristina; Baiocchi, Chiara; Bongioanni, Paolo; Cova, Emanuela; Guareschi, Stefania; Metelli, Maria Rita; Rossi, Bruno; Sbalsi, Ilaria; Cuccia, Maria Clara; Ceroni, Mauro.

In: Journal of Neuroimmunology, Vol. 194, No. 1-2, 02.2008, p. 123-131.

Research output: Contribution to journalArticle

Cereda, C, Baiocchi, C, Bongioanni, P, Cova, E, Guareschi, S, Metelli, MR, Rossi, B, Sbalsi, I, Cuccia, MC & Ceroni, M 2008, 'TNF and sTNFR1/2 plasma levels in ALS patients', Journal of Neuroimmunology, vol. 194, no. 1-2, pp. 123-131. https://doi.org/10.1016/j.jneuroim.2007.10.028
Cereda C, Baiocchi C, Bongioanni P, Cova E, Guareschi S, Metelli MR et al. TNF and sTNFR1/2 plasma levels in ALS patients. Journal of Neuroimmunology. 2008 Feb;194(1-2):123-131. https://doi.org/10.1016/j.jneuroim.2007.10.028
Cereda, Cristina ; Baiocchi, Chiara ; Bongioanni, Paolo ; Cova, Emanuela ; Guareschi, Stefania ; Metelli, Maria Rita ; Rossi, Bruno ; Sbalsi, Ilaria ; Cuccia, Maria Clara ; Ceroni, Mauro. / TNF and sTNFR1/2 plasma levels in ALS patients. In: Journal of Neuroimmunology. 2008 ; Vol. 194, No. 1-2. pp. 123-131.
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