TNF and sTNFR1/2 plasma levels in ALS patients

Cristina Cereda, Chiara Baiocchi, Paolo Bongioanni, Emanuela Cova, Stefania Guareschi, Maria Rita Metelli, Bruno Rossi, Ilaria Sbalsi, Maria Clara Cuccia, Mauro Ceroni

Research output: Contribution to journalArticle

Abstract

The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subjects. The genetic analysis of the polymorphisms of TNF-alpha, TNF-R1 and TNF-R2 showed no statistically significant differences in alleles and genotype frequencies between patients and controls. These data suggest a participation of the immune system in response to as far unknown intracellular signals.

Original languageEnglish
Pages (from-to)123-131
Number of pages9
JournalJournal of Neuroimmunology
Volume194
Issue number1-2
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Amyotrophic lateral sclerosis
  • Plasma
  • TNF-alpha
  • TNF-R1
  • TNF-R2

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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  • Cite this

    Cereda, C., Baiocchi, C., Bongioanni, P., Cova, E., Guareschi, S., Metelli, M. R., Rossi, B., Sbalsi, I., Cuccia, M. C., & Ceroni, M. (2008). TNF and sTNFR1/2 plasma levels in ALS patients. Journal of Neuroimmunology, 194(1-2), 123-131. https://doi.org/10.1016/j.jneuroim.2007.10.028