TNF-Based Limb Perfusion for Cutaneous Melanoma in Transit Metastases: Suggestions for Modification of the Perfusional Schedule

Carlo Riccardo Rossi, M. Foletto, S. Mocellin, P. L. Pilati, L. Campana, D. Ribello, M. Lise

Research output: Contribution to journalArticle

Abstract

Isolated limb perfusion (ILP) is currently considered the standard treatment for melanoma patients with extensive in-transit disease, and L-PAM, combined or not with TNF, represents the most active drug. We here report on our clinical experience with TNF-based limb perfusion. Thirty-seven stage III patients underwent TNF-based limb perfusion, 22 with bulky disease, 15 with recurrences after perfusion with L-PAM. Ten patients were enrolled in a phase I-II study and treated with escalating doses of TNF (0.5-3 mg). The impact of disease burden, temperature, perfusion duration was assessed on tumor response. No postoperative death was observed. No significant systemic toxicity was recorded. Locoregional toxicity was G5 in one patient, G3 in 2, G2 in 9 and G1 in 25. Twenty-four (66%) patients had complete response, 11 (31%) partial and 1 (3%) no change. After a median follow-up of 20 months 14 (38%) patients are NED, 10 (27%) are AWD and 13 (35%) DOD. No significant statistical difference for tumor response were seen for disease burden, ILP temperatures and duration. Our results showed that it is possible to modify the perfusion schedule, without compromising the response rate but with lower cost and toxicity.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalJournal of Experimental and Clinical Cancer Research
Volume22
Issue number4 SUPPL.
Publication statusPublished - Dec 2003

Keywords

  • In Transit metastases
  • Isolated limb perfusion
  • Melanoma
  • TNF

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'TNF-Based Limb Perfusion for Cutaneous Melanoma in Transit Metastases: Suggestions for Modification of the Perfusional Schedule'. Together they form a unique fingerprint.

  • Cite this