Tnf serum leves in amyotrophic lateral sclerosis

D. Facchetti, T. Bachetti, A. Micheli, C. Camana, G. Mora, L. Mazzini, M. Poloni

Research output: Contribution to journalArticlepeer-review


Recently, it has been suggested that apoptotic neuron death might occur in ALS. TNF-α is a cytokine able to induced apoptosis in experimental settings. Elevated TNF-α has been observed in Parkinson disease and Alzheimer dementia. We tested the hypothesis that TNF system is activated in ALS. The study population consisted of 51 ALS patients (mean age 58±9) and 36 age-matched healthy subjects. ALS diagnosis was done according to El Escorial criteria. Cases with onset under age 25, with purely progressive muscular atrophy, primary lateral sclerosis, and cases with associated significant concomitant diseases such as infection, renal failure, pulmonary disease and malignancy were excluded. The severity of the disease was evaluated by means of Noms scale, MRC score, and FVC. Blood samples for TNF measurements were taken within 9 a.m. and collected into sterile tubes. Serum TNF(X, and its soluble receptors, sTNF-RI and sTNF-RH, were assessed by ELISA kits. Mean TNF-α was significantly increased in ALS patients with respect to healthy subjects (29.9±8.6 vs 23.2±4.8 pg/mL, p

Original languageEnglish
Pages (from-to)23
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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