To Die or Not to Die: Sema3E Rules the Game

Luca Tamagnone, Michael Rehman

Research output: Contribution to journalArticlepeer-review


Sema3E, a ligand for PlexinD1, controls angiogenesis and promotes cancer invasion and metastasis. In this issue of Cancer Cell, Luchino and colleagues report that Sema3E also ensures breast cancer cell viability byblocking a previously unknown proapoptotic signaling cascade elicited by unliganded PlexinD1, thus behaving as a "dependence receptor.".

Original languageEnglish
Pages (from-to)564-566
Number of pages3
JournalCancer Cell
Issue number5
Publication statusPublished - Nov 11 2013

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology


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