Tobacco and alcohol in relation to male breast cancer

An analysis of the male breast cancer pooling project consortium

Michael B. Cook, Pascal Guénel, Susan M. Gapstur, Piet A. Van Den Brandt, Karin B. Michels, John T. Casagrande, Rosie Cooke, Stephen K. Van Den Eeden, Marianne Ewertz, Roni T. Falk, Mia M. Gaudet, George Gkiokas, Laurel A. Habel, Ann W. Hsing, Kenneth Johnson, Laurence N. Kolonel, Carlo La Vecchia, Elsebeth Lynge, Jay H. Lubin, Valerie A. McCormack & 10 others Eva Negri, Håkan Olsson, Dominick Parisi, Eleni Th Petridou, Elio Riboli, Howard D. Sesso, Anthony Swerdlow, David B. Thomas, Walter C. Willett, Louise A. Brinton

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) ORs and 95% confidence intervals (CI), which were then combined using fixed-effects metaanalysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one subanalysis of very high recent alcohol consumption (>60 g/day) was tentatively associated with malebreast cancer (ORunexposed referent = 1.29; 95%CI, 0.97-1.71; OR>0- =1.36; 95% CI, 1.04-1.77). Specificalcoholic beverage types were not associated with male breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project, we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer.

Original languageEnglish
Pages (from-to)520-531
Number of pages12
JournalCancer Epidemiology Biomarkers and Prevention
Volume24
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Male Breast Neoplasms
Tobacco
Alcohols
Smoking
Confidence Intervals
Alcohol Drinking
Smokeless Tobacco
Beverages
Tobacco Use
Carcinogens
Body Mass Index
Cohort Studies
Logistic Models

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Cook, M. B., Guénel, P., Gapstur, S. M., Van Den Brandt, P. A., Michels, K. B., Casagrande, J. T., ... Brinton, L. A. (2015). Tobacco and alcohol in relation to male breast cancer: An analysis of the male breast cancer pooling project consortium. Cancer Epidemiology Biomarkers and Prevention, 24(3), 520-531. https://doi.org/10.1158/1055-9965.EPI-14-1009

Tobacco and alcohol in relation to male breast cancer : An analysis of the male breast cancer pooling project consortium. / Cook, Michael B.; Guénel, Pascal; Gapstur, Susan M.; Van Den Brandt, Piet A.; Michels, Karin B.; Casagrande, John T.; Cooke, Rosie; Van Den Eeden, Stephen K.; Ewertz, Marianne; Falk, Roni T.; Gaudet, Mia M.; Gkiokas, George; Habel, Laurel A.; Hsing, Ann W.; Johnson, Kenneth; Kolonel, Laurence N.; La Vecchia, Carlo; Lynge, Elsebeth; Lubin, Jay H.; McCormack, Valerie A.; Negri, Eva; Olsson, Håkan; Parisi, Dominick; Petridou, Eleni Th; Riboli, Elio; Sesso, Howard D.; Swerdlow, Anthony; Thomas, David B.; Willett, Walter C.; Brinton, Louise A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 24, No. 3, 01.03.2015, p. 520-531.

Research output: Contribution to journalArticle

Cook, MB, Guénel, P, Gapstur, SM, Van Den Brandt, PA, Michels, KB, Casagrande, JT, Cooke, R, Van Den Eeden, SK, Ewertz, M, Falk, RT, Gaudet, MM, Gkiokas, G, Habel, LA, Hsing, AW, Johnson, K, Kolonel, LN, La Vecchia, C, Lynge, E, Lubin, JH, McCormack, VA, Negri, E, Olsson, H, Parisi, D, Petridou, ET, Riboli, E, Sesso, HD, Swerdlow, A, Thomas, DB, Willett, WC & Brinton, LA 2015, 'Tobacco and alcohol in relation to male breast cancer: An analysis of the male breast cancer pooling project consortium', Cancer Epidemiology Biomarkers and Prevention, vol. 24, no. 3, pp. 520-531. https://doi.org/10.1158/1055-9965.EPI-14-1009
Cook, Michael B. ; Guénel, Pascal ; Gapstur, Susan M. ; Van Den Brandt, Piet A. ; Michels, Karin B. ; Casagrande, John T. ; Cooke, Rosie ; Van Den Eeden, Stephen K. ; Ewertz, Marianne ; Falk, Roni T. ; Gaudet, Mia M. ; Gkiokas, George ; Habel, Laurel A. ; Hsing, Ann W. ; Johnson, Kenneth ; Kolonel, Laurence N. ; La Vecchia, Carlo ; Lynge, Elsebeth ; Lubin, Jay H. ; McCormack, Valerie A. ; Negri, Eva ; Olsson, Håkan ; Parisi, Dominick ; Petridou, Eleni Th ; Riboli, Elio ; Sesso, Howard D. ; Swerdlow, Anthony ; Thomas, David B. ; Willett, Walter C. ; Brinton, Louise A. / Tobacco and alcohol in relation to male breast cancer : An analysis of the male breast cancer pooling project consortium. In: Cancer Epidemiology Biomarkers and Prevention. 2015 ; Vol. 24, No. 3. pp. 520-531.
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abstract = "Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) ORs and 95{\%} confidence intervals (CI), which were then combined using fixed-effects metaanalysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one subanalysis of very high recent alcohol consumption (>60 g/day) was tentatively associated with malebreast cancer (ORunexposed referent = 1.29; 95{\%}CI, 0.97-1.71; OR>0- =1.36; 95{\%} CI, 1.04-1.77). Specificalcoholic beverage types were not associated with male breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project, we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer.",
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T1 - Tobacco and alcohol in relation to male breast cancer

T2 - An analysis of the male breast cancer pooling project consortium

AU - Cook, Michael B.

AU - Guénel, Pascal

AU - Gapstur, Susan M.

AU - Van Den Brandt, Piet A.

AU - Michels, Karin B.

AU - Casagrande, John T.

AU - Cooke, Rosie

AU - Van Den Eeden, Stephen K.

AU - Ewertz, Marianne

AU - Falk, Roni T.

AU - Gaudet, Mia M.

AU - Gkiokas, George

AU - Habel, Laurel A.

AU - Hsing, Ann W.

AU - Johnson, Kenneth

AU - Kolonel, Laurence N.

AU - La Vecchia, Carlo

AU - Lynge, Elsebeth

AU - Lubin, Jay H.

AU - McCormack, Valerie A.

AU - Negri, Eva

AU - Olsson, Håkan

AU - Parisi, Dominick

AU - Petridou, Eleni Th

AU - Riboli, Elio

AU - Sesso, Howard D.

AU - Swerdlow, Anthony

AU - Thomas, David B.

AU - Willett, Walter C.

AU - Brinton, Louise A.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) ORs and 95% confidence intervals (CI), which were then combined using fixed-effects metaanalysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one subanalysis of very high recent alcohol consumption (>60 g/day) was tentatively associated with malebreast cancer (ORunexposed referent = 1.29; 95%CI, 0.97-1.71; OR>0- =1.36; 95% CI, 1.04-1.77). Specificalcoholic beverage types were not associated with male breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project, we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer.

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