Abstract
Background/Aim: Smoking is a recognized risk factor for pancreatic cancer. The aim of this study was to perform a meta-analysis to provide a robust estimate of the strength of the association between smoking and pancreatic cancer, to determine the risk of pipe and cigar smoking, and to estimate the duration of an elevated risk after smoking cessation. Methods: We performed a meta-analysis of 82 published studies containing epidemiologic information about smoking and pancreatic cancer. Information on studies published between 1950 and 2007 was abstracted and prepared for analysis using standard meta-analytic procedures. Results: The overall risk of pancreatic cancer estimated from the combined results for current and former smokers was, respectively, 1.74 (95% CI 1.61-1.87) and 1.2 (95% CI 1.11-1.29). The risk of pancreatic cancer for current and former pipe and/or cigar smokers was respectively 1.47 (95% CI 1.17-1.83) and 1.29 (95% CI 0.68-2.45). For former cigarette smokers, the risk remains elevated for a minimum of 10 years after cessation. Conclusions: Based on estimates from four continents, smoking cigarettes causes a 75% increase in the risk of pancreatic cancer compared to non-smokers, and the risk persists for a minimum of 10 years after smoking cessation. This implies that in a population where the prevalence of smoking is 30%, the population's attributable risk (the proportion of pancreatic cancer explained by smoking) is estimated to be 20%.
| Original language | English |
|---|---|
| Pages (from-to) | 535-545 |
| Number of pages | 11 |
| Journal | Langenbeck's Archives of Surgery |
| Volume | 393 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2008 |
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Keywords
- Epidemiology
- Meta-analysis
- Pancreatic cancer
- Smoking
- Tobacco
ASJC Scopus subject areas
- Surgery
Cite this
Tobacco and the risk of pancreatic cancer : A review and meta-analysis. / Iodice, Simona; Gandini, Sara; Maisonneuve, Patrick; Lowenfels, Albert B.
In: Langenbeck's Archives of Surgery, Vol. 393, No. 4, 07.2008, p. 535-545.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tobacco and the risk of pancreatic cancer
T2 - A review and meta-analysis
AU - Iodice, Simona
AU - Gandini, Sara
AU - Maisonneuve, Patrick
AU - Lowenfels, Albert B.
PY - 2008/7
Y1 - 2008/7
N2 - Background/Aim: Smoking is a recognized risk factor for pancreatic cancer. The aim of this study was to perform a meta-analysis to provide a robust estimate of the strength of the association between smoking and pancreatic cancer, to determine the risk of pipe and cigar smoking, and to estimate the duration of an elevated risk after smoking cessation. Methods: We performed a meta-analysis of 82 published studies containing epidemiologic information about smoking and pancreatic cancer. Information on studies published between 1950 and 2007 was abstracted and prepared for analysis using standard meta-analytic procedures. Results: The overall risk of pancreatic cancer estimated from the combined results for current and former smokers was, respectively, 1.74 (95% CI 1.61-1.87) and 1.2 (95% CI 1.11-1.29). The risk of pancreatic cancer for current and former pipe and/or cigar smokers was respectively 1.47 (95% CI 1.17-1.83) and 1.29 (95% CI 0.68-2.45). For former cigarette smokers, the risk remains elevated for a minimum of 10 years after cessation. Conclusions: Based on estimates from four continents, smoking cigarettes causes a 75% increase in the risk of pancreatic cancer compared to non-smokers, and the risk persists for a minimum of 10 years after smoking cessation. This implies that in a population where the prevalence of smoking is 30%, the population's attributable risk (the proportion of pancreatic cancer explained by smoking) is estimated to be 20%.
AB - Background/Aim: Smoking is a recognized risk factor for pancreatic cancer. The aim of this study was to perform a meta-analysis to provide a robust estimate of the strength of the association between smoking and pancreatic cancer, to determine the risk of pipe and cigar smoking, and to estimate the duration of an elevated risk after smoking cessation. Methods: We performed a meta-analysis of 82 published studies containing epidemiologic information about smoking and pancreatic cancer. Information on studies published between 1950 and 2007 was abstracted and prepared for analysis using standard meta-analytic procedures. Results: The overall risk of pancreatic cancer estimated from the combined results for current and former smokers was, respectively, 1.74 (95% CI 1.61-1.87) and 1.2 (95% CI 1.11-1.29). The risk of pancreatic cancer for current and former pipe and/or cigar smokers was respectively 1.47 (95% CI 1.17-1.83) and 1.29 (95% CI 0.68-2.45). For former cigarette smokers, the risk remains elevated for a minimum of 10 years after cessation. Conclusions: Based on estimates from four continents, smoking cigarettes causes a 75% increase in the risk of pancreatic cancer compared to non-smokers, and the risk persists for a minimum of 10 years after smoking cessation. This implies that in a population where the prevalence of smoking is 30%, the population's attributable risk (the proportion of pancreatic cancer explained by smoking) is estimated to be 20%.
KW - Epidemiology
KW - Meta-analysis
KW - Pancreatic cancer
KW - Smoking
KW - Tobacco
UR - http://www.scopus.com/inward/record.url?scp=43149114451&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43149114451&partnerID=8YFLogxK
U2 - 10.1007/s00423-007-0266-2
DO - 10.1007/s00423-007-0266-2
M3 - Article
VL - 393
SP - 535
EP - 545
JO - Langenbecks Archiv fur Chirurgie
JF - Langenbecks Archiv fur Chirurgie
SN - 0023-8236
IS - 4
ER -