Tocilizumab in MOG-antibody spectrum disorder: a case report

G Novi, M Gastaldi, D Franciotta, G Pesce, L Benedetti, A Uccelli

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Myelin oligodendrocyte glycoprotein antibody-related spectrum disorders (MOG-SD) are a heterogeneous group of inflammatory demyelinating diseases of the central nervous system, usually responsive to conventional immunosuppressive therapies. However, knowledge about treatment of non-responder patients is scarce.

METHODS: We report on a 20-year-old MOG-SD patient who experienced clinical deterioration despite rituximab-induced B-cell depletion.

RESULTS: Rescue therapy with tocilizumab (TCZ) prevented further relapses, with reduction of spinal-cord load on MRI, and a remarkable reduction of disability at the two-year follow-up.

CONCLUSION: Our observations suggest that TCZ could induce clinico-radiologic improvements, which make it as an option for the treatment of MOG-SD.

Original languageEnglish
Pages (from-to)312-314
Number of pages3
JournalMultiple Sclerosis and Related Disorders
Volume27
DOIs
Publication statusE-pub ahead of print - Nov 13 2018

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Myelin-Oligodendrocyte Glycoprotein
Antibodies
Demyelinating Diseases
Therapeutics
Immunosuppressive Agents
Spinal Cord
B-Lymphocytes
Central Nervous System
Recurrence
tocilizumab

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Tocilizumab in MOG-antibody spectrum disorder : a case report. / Novi, G; Gastaldi, M; Franciotta, D; Pesce, G; Benedetti, L; Uccelli, A.

In: Multiple Sclerosis and Related Disorders, Vol. 27, 13.11.2018, p. 312-314.

Research output: Contribution to journalArticle

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AU - Novi, G

AU - Gastaldi, M

AU - Franciotta, D

AU - Pesce, G

AU - Benedetti, L

AU - Uccelli, A

N1 - Copyright © 2018. Published by Elsevier B.V.

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