Toenail selenium and risk of type 2 diabetes: The ORDET cohort study

Marco Vinceti, Sara Grioni, Dorothea Alber, Dario Consonni, Carlotta Malagoli, Claudia Agnoli, Marcella Malavolti, Valeria Pala, Vittorio Krogh, Sabina Sieri

Research output: Contribution to journalArticle

Abstract

Epidemiologic studies, particularly randomized controlled trials, have shown a direct relation between dietary and environmental exposure to the metalloid selenium and risk of type 2 diabetes. We investigated the association between baseline toenail selenium levels and diabetes occurrence in a case-control study nested in ORDET, a population-based female cohort in Northern Italy. After a median follow-up of 16 years, we identified 226 cases of type 2 diabetes cases and 395 age-matched control women with available toenail samples at baseline. The multivariate odds ratios of diabetes in increasing a priori defined categories of toenail selenium exposure were 1.09 (95% confidence interval 0.61, 1.96), 0.71 (0.38, 1.34) and 1.14 (0.46, 2.80) compared with the lowest category. The results were not substantially altered when quartile distribution of toenail selenium in controls was used to define exposure categories. Spline regression analysis did not show homogeneous risk trends. Overall, we did not find an association between toenail selenium and subsequent development of diabetes. Since the diabetogenic activity of selenium is strongly supported by experimental studies and some observational investigations, our null results might be explained by the limitations of overall selenium toenail content to assess environmental exposure to selenium species of etiologic relevance in the study population.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Volume29
DOIs
Publication statusPublished - Jan 1 2015

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Medical problems
Selenium
Nails
Type 2 Diabetes Mellitus
Cohort Studies
Environmental Exposure
Metalloids
Regression analysis
Splines
Italy
Population
Observational Studies
Case-Control Studies
Epidemiologic Studies
Randomized Controlled Trials
Odds Ratio
Regression Analysis
Confidence Intervals

Keywords

  • Cohort study
  • Diabetes
  • Risk assessment
  • Selenium
  • Toenails

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Molecular Medicine

Cite this

Toenail selenium and risk of type 2 diabetes : The ORDET cohort study. / Vinceti, Marco; Grioni, Sara; Alber, Dorothea; Consonni, Dario; Malagoli, Carlotta; Agnoli, Claudia; Malavolti, Marcella; Pala, Valeria; Krogh, Vittorio; Sieri, Sabina.

In: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), Vol. 29, 01.01.2015, p. 145-150.

Research output: Contribution to journalArticle

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