TOFE human-B-cell-line-based adsorption-inhibition assay to detect HCV neutralizing antibodies

M. B. Valli, L. Bertolini, A. Manzin, M. Clementi, G. Carloni

Research output: Contribution to journalArticlepeer-review

Abstract

We previously demonstrated that the human lymphoblastoid B-cell line (LCL) TOFE, derived from normal human bone marrow, is permissive to HCV infection. In this report we developed an in vitro HCV adsorption-inhibition assay based on TOFE cells, to reveal the presence of neutralizing antibodies in sera from acutely infected patients.

Original languageEnglish
Pages (from-to)331-333
Number of pages3
JournalResearch in Virology
Volume149
Issue number5
DOIs
Publication statusPublished - Sep 1998

Keywords

  • B-cell line
  • HCV
  • Neutralizing antibodies
  • PCR
  • TOFE cells

ASJC Scopus subject areas

  • Virology
  • Immunology

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