Tolerability and use in co-administration of pregabalin in affective patients: A 6-month prospective naturalistic study

Cristina Dobrea, Massimiliano Buoli, Chiara Arici, Giulia Camuri, Bernardo Dell'Osso, Alfredo Carlo Altamura

Research output: Contribution to journalArticlepeer-review


Objective: The aims of the present study were to investigate the main demographic and clinical characteristics, comorbidity patterns, use in association and tolerability of pregabalin in a sample of patients with affective disorders, and to compare demographic and clinical variables of the groups divided, according to the treatment pregabalin was associated with. Methods: One hundred and fourteen consecutive outpatients, with anxiety and/or depressive disorders with or without comorbidity, were started on pregabalin, assessed and interviewed and their demographic data, associated therapy, tolerability and side effects collected over an observational period of 6 months. Results: The most frequent primary diagnoses were mood disorders (49.1%) and generalized anxiety disorder (21.9%). The most commonly associated treatments were antidepressants (66.7%) and mood stabilizers (15.8%). The most frequent side effects were sedation (3.4%), dizziness (0.9%), nausea (0.9%), diarrhea (0.9%), cough (0.9%) and peripheral edema (0.9%). When patients were divided according to the co-treatments, subgroups differed in terms of prescription of benzodiazepines (χ2 15.25, df 6, p 0.013, phi 0.37), with the most frequent use of these molecules in patients co-treated with tricyclic antidepressants and minor use in the selective serotonin reuptake inhibitors group. Conclusions: Differences in the co-administration of benzodiazepines might suggest a stronger anxiolytic effect when pregabalin is combined with specific psychotropic drugs (e.g., SSRIs).

Original languageEnglish
Pages (from-to)893-899
Number of pages7
JournalExpert Opinion on Drug Safety
Issue number6
Publication statusPublished - Nov 2012


  • Affective disorders
  • Benzodiazepines
  • Polytherapy
  • Pregabalin
  • Tolerability

ASJC Scopus subject areas

  • Pharmacology (medical)


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