Tolerability of raltitrexed ('Tomudex') in elderly patients with colorectal cancer

Adriana Romiti; Giuseppe Tonini; Daniele Santini; Marisa Di Seri; Raffaele Masciangelo; Silvia Mezi; Attilio Verì; Lucia Santuari; Bruno Vincenzi; Antonio Brescia; Paolo Marchei; Luigi Frati; Silverio Tomao

Tolerability of raltitrexed ('Tomudex') in elderly patients with colorectal cancer

Adriana Romiti, Giuseppe Tonini, Daniele Santini, Marisa Di Seri, Raffaele Masciangelo, Silvia Mezi, Attilio Verì, Lucia Santuari, Bruno Vincenzi, Antonio Brescia, Paolo Marchei, Luigi Frati, Silverio Tomao

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Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Colorectal cancer (CRC) is one of the major health problems of the Western world and the proportion of elderly patients with CRC is growing. Raltitrexed ('Tomudex'), a specific thymidylate synthase inhibitor, has shown efficacy and manageable toxicity in elderly CRC patients. In this retrospective study, the tolerability of raltitrexed in patients with CRC was examined in relation to age. Patients and Methods: Toxicity parameters, graded according to World Health Organization criteria, were assessed in two patient groups: 2 as a 15-minute intravenous infusion every 3 weeks) were aged >70 years (M:F 28:22; Eastern Cooperative Oncology Group performance status 0-1:2 38:12). Results: Overall, 437 cycles of chemotherapy were administered and grade 3-4 toxicity was reported in

Original language	English
Pages (from-to)	3071-3076
Number of pages	6
Journal	Anticancer Research
Volume	22
Issue number	5
Publication status	Published - Sep 2002

Keywords

Chemotherapy
Colorectal cancer
Elderly
Raltitrexed

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

Tolerability of raltitrexed ('Tomudex') in elderly patients with colorectal cancer. / Romiti, Adriana; Tonini, Giuseppe; Santini, Daniele; Di Seri, Marisa; Masciangelo, Raffaele; Mezi, Silvia; Verì, Attilio; Santuari, Lucia; Vincenzi, Bruno; Brescia, Antonio; Marchei, Paolo; Frati, Luigi; Tomao, Silverio.

In: Anticancer Research, Vol. 22, No. 5, 09.2002, p. 3071-3076.

Research output: Contribution to journal › Article › peer-review

Romiti, Adriana ; Tonini, Giuseppe ; Santini, Daniele ; Di Seri, Marisa ; Masciangelo, Raffaele ; Mezi, Silvia ; Verì, Attilio ; Santuari, Lucia ; Vincenzi, Bruno ; Brescia, Antonio ; Marchei, Paolo ; Frati, Luigi ; Tomao, Silverio. / Tolerability of raltitrexed ('Tomudex') in elderly patients with colorectal cancer. In: Anticancer Research. 2002 ; Vol. 22, No. 5. pp. 3071-3076.

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abstract = "Purpose: Colorectal cancer (CRC) is one of the major health problems of the Western world and the proportion of elderly patients with CRC is growing. Raltitrexed ('Tomudex'), a specific thymidylate synthase inhibitor, has shown efficacy and manageable toxicity in elderly CRC patients. In this retrospective study, the tolerability of raltitrexed in patients with CRC was examined in relation to age. Patients and Methods: Toxicity parameters, graded according to World Health Organization criteria, were assessed in two patient groups: 2 as a 15-minute intravenous infusion every 3 weeks) were aged >70 years (M:F 28:22; Eastern Cooperative Oncology Group performance status 0-1:2 38:12). Results: Overall, 437 cycles of chemotherapy were administered and grade 3-4 toxicity was reported in ",

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AU - Romiti, Adriana

AU - Tonini, Giuseppe

AU - Santini, Daniele

AU - Di Seri, Marisa

AU - Masciangelo, Raffaele

AU - Mezi, Silvia

AU - Verì, Attilio

AU - Santuari, Lucia

AU - Vincenzi, Bruno

AU - Brescia, Antonio

AU - Marchei, Paolo

AU - Frati, Luigi

AU - Tomao, Silverio

PY - 2002/9

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AB - Purpose: Colorectal cancer (CRC) is one of the major health problems of the Western world and the proportion of elderly patients with CRC is growing. Raltitrexed ('Tomudex'), a specific thymidylate synthase inhibitor, has shown efficacy and manageable toxicity in elderly CRC patients. In this retrospective study, the tolerability of raltitrexed in patients with CRC was examined in relation to age. Patients and Methods: Toxicity parameters, graded according to World Health Organization criteria, were assessed in two patient groups: 2 as a 15-minute intravenous infusion every 3 weeks) were aged >70 years (M:F 28:22; Eastern Cooperative Oncology Group performance status 0-1:2 38:12). Results: Overall, 437 cycles of chemotherapy were administered and grade 3-4 toxicity was reported in

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Tolerability of raltitrexed ('Tomudex') in elderly patients with colorectal cancer

Abstract

Keywords

ASJC Scopus subject areas

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