Abstract
Purpose: Colorectal cancer (CRC) is one of the major health problems of the Western world and the proportion of elderly patients with CRC is growing. Raltitrexed ('Tomudex'), a specific thymidylate synthase inhibitor, has shown efficacy and manageable toxicity in elderly CRC patients. In this retrospective study, the tolerability of raltitrexed in patients with CRC was examined in relation to age. Patients and Methods: Toxicity parameters, graded according to World Health Organization criteria, were assessed in two patient groups: 2 as a 15-minute intravenous infusion every 3 weeks) were aged >70 years (M:F 28:22; Eastern Cooperative Oncology Group performance status 0-1:2 38:12). Results: Overall, 437 cycles of chemotherapy were administered and grade 3-4 toxicity was reported in
Original language | English |
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Pages (from-to) | 3071-3076 |
Number of pages | 6 |
Journal | Anticancer Research |
Volume | 22 |
Issue number | 5 |
Publication status | Published - Sep 2002 |
Keywords
- Chemotherapy
- Colorectal cancer
- Elderly
- Raltitrexed
ASJC Scopus subject areas
- Cancer Research
- Oncology