Tolerance in intestinal inflammation and cancer

Marisa Vulcano, Silvio Danese, Antonio Sica

Research output: Contribution to journalArticlepeer-review

Abstract

In the human body, mucosal surfaces of the intestinal tract are the largest and one of the most complex parts of the immune system. These surfaces are covered by a layer of epithelial cells which allows efficient absorption of nutrients but also serves to separate the intestine from an environment loaded with potential harmful agents. Discrimination between beneficial commensal bacteria, harmless antigens and pathogenic microorganisms is a central issue in the role that gut immune cells play in maintaining the balance between immune response and tolerance. However, the basis of this discrimination in the mucosal immune system, where this occurs and how it can affect both local and systemic responses is not yet well understood. Nevertheless, antigen uptake and presentation seems to be a crucial factor in this issue. In this review, we will discuss the key role of immune intestinal cells in the development of mucosal immunity, tolerance and disease.

Original languageEnglish
Pages (from-to)404-412
Number of pages9
JournalCurrent Drug Targets
Volume9
Issue number5
DOIs
Publication statusPublished - May 2008

Keywords

  • Dendritic Cells
  • Intestinal Epithelial Cells
  • Mesenteric Lymph Nodes
  • Peyers patches
  • T cell tolerance

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

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