Tolerance: Pregnancy matters

Franco Locatelli

Research output: Contribution to journalArticlepeer-review


In this issue of Blood, van Halteren and colleagues demonstrate that not only antigen-specific CD8 + CTLs, but also antigen-specific CD8 + T regs can emerge during pregnancy and persist over time when mother and offspring differ for minor histocompatibility antigens.1 The relative ratio between these 2 populations, either promoting aggression against allogeneic tissues or tumor cells or tolerance toward alloantigens, is of potential great relevance in the context of HSCT.

Original languageEnglish
Pages (from-to)2208-2209
Number of pages2
Issue number11
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology


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