Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells

Peter Terness, Marinos Kallikourdis, Alexander G. Betz, Gabriel A. Rabinovich, Shigeru Saito, David A. Clark

Research output: Contribution to journalArticlepeer-review

Abstract

Probelm: Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid? Method of study: Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. Results and Conclusion: A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.

Original languageEnglish
Pages (from-to)238-254
Number of pages17
JournalAmerican Journal of Reproductive Immunology
Volume58
Issue number3
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Galectin-1
  • IDO
  • Pregnancy immunology
  • Tolerance
  • Treg cells

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

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