Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells

Peter Terness; Marinos Kallikourdis; Alexander G. Betz; Gabriel A. Rabinovich; Shigeru Saito; David A. Clark

doi:10.1111/j.1600-0897.2007.00510.x

Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells

Peter Terness, Marinos Kallikourdis, Alexander G. Betz, Gabriel A. Rabinovich, Shigeru Saito, David A. Clark

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Probelm: Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid? Method of study: Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. Results and Conclusion: A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.

Original language	English
Pages (from-to)	238-254
Number of pages	17
Journal	American Journal of Reproductive Immunology
Volume	58
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-0897.2007.00510.x
Publication status	Published - Sep 2007

Keywords

Galectin-1
IDO
Pregnancy immunology
Tolerance
Treg cells

ASJC Scopus subject areas

Immunology
Obstetrics and Gynaecology

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Tolerance signaling molecules and pregnancy : IDO, galectins, and the renaissance of regulatory T cells. / Terness, Peter; Kallikourdis, Marinos; Betz, Alexander G.; Rabinovich, Gabriel A.; Saito, Shigeru; Clark, David A.

In: American Journal of Reproductive Immunology, Vol. 58, No. 3, 09.2007, p. 238-254.

Research output: Contribution to journal › Article › peer-review

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