TY - JOUR
T1 - Tolerance signaling molecules and pregnancy
T2 - IDO, galectins, and the renaissance of regulatory T cells
AU - Terness, Peter
AU - Kallikourdis, Marinos
AU - Betz, Alexander G.
AU - Rabinovich, Gabriel A.
AU - Saito, Shigeru
AU - Clark, David A.
PY - 2007/9
Y1 - 2007/9
N2 - Probelm: Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid? Method of study: Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. Results and Conclusion: A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.
AB - Probelm: Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid? Method of study: Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. Results and Conclusion: A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.
KW - Galectin-1
KW - IDO
KW - Pregnancy immunology
KW - Tolerance
KW - Treg cells
UR - http://www.scopus.com/inward/record.url?scp=34547884318&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547884318&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0897.2007.00510.x
DO - 10.1111/j.1600-0897.2007.00510.x
M3 - Article
C2 - 17681041
AN - SCOPUS:34547884318
VL - 58
SP - 238
EP - 254
JO - Early pregnancy (Online)
JF - Early pregnancy (Online)
SN - 1046-7408
IS - 3
ER -