Abstract
Objective. To investigate potential associations between toll-like receptor 4 (TLR4) gene polymorphisms and susceptibility to, and clinical features of giant cell arteritis (GCA). Methods. A total of 155 patients with biopsy-proven GCA who were residents of Reggio Emilia, Italy, and 210 population-based controls from the same geographical area were genotyped for two coding single nucleotide polymorphisms of TLR4 (Asp299Gly and Thr399Ile) by molecular methods. The patients were subgrouped according to the presence or absence of polymyalgia rheumatica and severe ischemic complications (visual loss and/or cerebrovascular accidents). Results. The distribution of allele and genotype frequencies did not differ significantly between GCA patients and healthy controls. Carriers of the -299 G allele (G/A+ G/G) [odds ratio (OR) 1.78, 95% confidence intervals (CI) 0.90-3.50)] were more frequent among GCA patients than among the controls, but the difference was not statistically significant. No significant associations were found when GCA patients with and without PMR or with and without severe ischemic complications were compared. Conclusion. Our data suggest that the TLR4 gene polymorphisms are not associated with susceptibility to, and clinical expression of, GCA in Italian patients.
| Original language | English |
|---|---|
| Journal | Clinical and Experimental Rheumatology |
| Volume | 27 |
| Issue number | 1 SUPPL. 52 |
| Publication status | Published - 2009 |
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Keywords
- Giant cell arteritis
- Ischemic complications
- Toll-like receptor 4
- Toll-like receptor 4 polymorphisms
ASJC Scopus subject areas
- Rheumatology
- Immunology
- Immunology and Allergy
Cite this
Toll-like receptor 4 (TLR4) gene polymorphisms in giant cell arteritis. / Boiardi, Luigi; Casali, Bruno; Farnetti, Enrico; Pipitone, Nicolò; Nicoli, Davide; Macchioni, PierLuigi; Cimino, Luca; Bajocchi, Gian Luigi; Catanoso, Maria Grazia; Pattacini, Laura; Ghinoi, Alessandra; Restuccia, Giovanna; Salvarani, Carlo.
In: Clinical and Experimental Rheumatology, Vol. 27, No. 1 SUPPL. 52, 2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Toll-like receptor 4 (TLR4) gene polymorphisms in giant cell arteritis
AU - Boiardi, Luigi
AU - Casali, Bruno
AU - Farnetti, Enrico
AU - Pipitone, Nicolò
AU - Nicoli, Davide
AU - Macchioni, PierLuigi
AU - Cimino, Luca
AU - Bajocchi, Gian Luigi
AU - Catanoso, Maria Grazia
AU - Pattacini, Laura
AU - Ghinoi, Alessandra
AU - Restuccia, Giovanna
AU - Salvarani, Carlo
PY - 2009
Y1 - 2009
N2 - Objective. To investigate potential associations between toll-like receptor 4 (TLR4) gene polymorphisms and susceptibility to, and clinical features of giant cell arteritis (GCA). Methods. A total of 155 patients with biopsy-proven GCA who were residents of Reggio Emilia, Italy, and 210 population-based controls from the same geographical area were genotyped for two coding single nucleotide polymorphisms of TLR4 (Asp299Gly and Thr399Ile) by molecular methods. The patients were subgrouped according to the presence or absence of polymyalgia rheumatica and severe ischemic complications (visual loss and/or cerebrovascular accidents). Results. The distribution of allele and genotype frequencies did not differ significantly between GCA patients and healthy controls. Carriers of the -299 G allele (G/A+ G/G) [odds ratio (OR) 1.78, 95% confidence intervals (CI) 0.90-3.50)] were more frequent among GCA patients than among the controls, but the difference was not statistically significant. No significant associations were found when GCA patients with and without PMR or with and without severe ischemic complications were compared. Conclusion. Our data suggest that the TLR4 gene polymorphisms are not associated with susceptibility to, and clinical expression of, GCA in Italian patients.
AB - Objective. To investigate potential associations between toll-like receptor 4 (TLR4) gene polymorphisms and susceptibility to, and clinical features of giant cell arteritis (GCA). Methods. A total of 155 patients with biopsy-proven GCA who were residents of Reggio Emilia, Italy, and 210 population-based controls from the same geographical area were genotyped for two coding single nucleotide polymorphisms of TLR4 (Asp299Gly and Thr399Ile) by molecular methods. The patients were subgrouped according to the presence or absence of polymyalgia rheumatica and severe ischemic complications (visual loss and/or cerebrovascular accidents). Results. The distribution of allele and genotype frequencies did not differ significantly between GCA patients and healthy controls. Carriers of the -299 G allele (G/A+ G/G) [odds ratio (OR) 1.78, 95% confidence intervals (CI) 0.90-3.50)] were more frequent among GCA patients than among the controls, but the difference was not statistically significant. No significant associations were found when GCA patients with and without PMR or with and without severe ischemic complications were compared. Conclusion. Our data suggest that the TLR4 gene polymorphisms are not associated with susceptibility to, and clinical expression of, GCA in Italian patients.
KW - Giant cell arteritis
KW - Ischemic complications
KW - Toll-like receptor 4
KW - Toll-like receptor 4 polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=70350162305&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350162305&partnerID=8YFLogxK
M3 - Article
C2 - 19646345
AN - SCOPUS:70350162305
VL - 27
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 1 SUPPL. 52
ER -