Abstract
Toll-like receptors (TLRs) form a family of pattern recognition receptors that have emerged as key mediators of innate immunity. These receptors sense invading microbes and initiate the immune response. TLR-mediated inflammation is an important pathogenic link between innate immunity and a diverse panel of clinical disorders. Among the processes in which TLRs play a role are cardiovascular disorders such as cardiac ischaemia, coronary artery disease, ventricular remodelling, cancer angiogenesis or transplant rejection. From these, many important opportunities for disease modification through TLR signalling manipulation can be imagined. Their role as potential targets for therapeutic intervention is just beginning to be appreciated and this article reviews the current status of these treatment strategies for cardiovascular disease.
| Original language | English |
|---|---|
| Pages (from-to) | 857-871 |
| Number of pages | 15 |
| Journal | Expert Opinion on Investigational Drugs |
| Volume | 15 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2006 |
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Keywords
- Cardiovascular disease
- Drug development
- Innate immune system
- Toll-like receptors
ASJC Scopus subject areas
- Pharmacology
Cite this
Toll-like receptor modulation in cardiovascular disease : A target for intervention? / Földes, Gábor; von Haehling, Stephan; Anker, Stefan D.
In: Expert Opinion on Investigational Drugs, Vol. 15, No. 8, 08.2006, p. 857-871.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Toll-like receptor modulation in cardiovascular disease
T2 - A target for intervention?
AU - Földes, Gábor
AU - von Haehling, Stephan
AU - Anker, Stefan D.
PY - 2006/8
Y1 - 2006/8
N2 - Toll-like receptors (TLRs) form a family of pattern recognition receptors that have emerged as key mediators of innate immunity. These receptors sense invading microbes and initiate the immune response. TLR-mediated inflammation is an important pathogenic link between innate immunity and a diverse panel of clinical disorders. Among the processes in which TLRs play a role are cardiovascular disorders such as cardiac ischaemia, coronary artery disease, ventricular remodelling, cancer angiogenesis or transplant rejection. From these, many important opportunities for disease modification through TLR signalling manipulation can be imagined. Their role as potential targets for therapeutic intervention is just beginning to be appreciated and this article reviews the current status of these treatment strategies for cardiovascular disease.
AB - Toll-like receptors (TLRs) form a family of pattern recognition receptors that have emerged as key mediators of innate immunity. These receptors sense invading microbes and initiate the immune response. TLR-mediated inflammation is an important pathogenic link between innate immunity and a diverse panel of clinical disorders. Among the processes in which TLRs play a role are cardiovascular disorders such as cardiac ischaemia, coronary artery disease, ventricular remodelling, cancer angiogenesis or transplant rejection. From these, many important opportunities for disease modification through TLR signalling manipulation can be imagined. Their role as potential targets for therapeutic intervention is just beginning to be appreciated and this article reviews the current status of these treatment strategies for cardiovascular disease.
KW - Cardiovascular disease
KW - Drug development
KW - Innate immune system
KW - Toll-like receptors
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U2 - 10.1517/13543784.15.8.857
DO - 10.1517/13543784.15.8.857
M3 - Article
C2 - 16859390
AN - SCOPUS:33746839212
VL - 15
SP - 857
EP - 871
JO - Expert Opinion on Investigational Drugs
JF - Expert Opinion on Investigational Drugs
SN - 1354-3784
IS - 8
ER -